Results 131 to 140 of about 29,786,749 (389)
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
MMseqs2: sensitive protein sequence searching for the analysis of massive data sets
bioRxiv, 2017 Sequencing costs have dropped much faster than Moore's law in the past decade, and sensitive sequence searching has become the main bottleneck in the analysis of large (meta)genomic datasets. While previous methods sacrificed sensitivity for speed gains,
Martin Steinegger, J. Söding
semanticscholar +1 more source
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Fundamental principles in drawing inference from sequence analysis
, 2010 Individual life courses are dynamic and can be represented as a sequence of states for some portion of their experiences. More generally, study of such sequences has been made in many fields around social science; for example, sociology, linguistics ...
King, Tom
core
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
Learning protein constitutive motifs from sequence data
eLife, 2019 Statistical analysis of evolutionary-related protein sequences provides information about their structure, function, and history. We show that Restricted Boltzmann Machines (RBM), designed to learn complex high-dimensional data and their statistical ...
Jérôme Tubiana +2 more
doaj +1 more source
Pair Analysis of Field Galaxies from the Red-Sequence Cluster Survey
, 2008 We study the evolution of the number of close companions of similar luminosities per galaxy (Nc) by choosing a volume-limited subset of the photometric redshift catalog from the Red-Sequence Cluster Survey (RCS-1).
B. C. Hsieh +6 more
core +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
DNA Steganalysis Using Deep Recurrent Neural Networks
, 2018 Recent advances in next-generation sequencing technologies have facilitated the use of deoxyribonucleic acid (DNA) as a novel covert channels in steganography.
Bae, Ho +3 more
core +1 more source
Sequence analysis of mutations and translocations across breast cancer subtypes
Nature, 2012 Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with an estimated 1.38 million new cases and 458,000 deaths in 2008 alone.
S. Banerji +46 more
semanticscholar +1 more source