Results 111 to 120 of about 3,077,972 (305)

Sequence alignment, mutual information, and dissimilarity measures for constructing phylogenies

, 2011
Background: Existing sequence alignment algorithms use heuristic scoring schemes based on biological expertise, which cannot be used as objective distance metrics.
Penner, Orion, Grassberger, Peter, Maya Paczuski, Paczuski Maya, Peter Grassberger, Orion Penner, Penner Orion, Grassberger Peter, Paczuski, Maya   +8 more
core   +1 more source

Pig genome sequence - analysis and publication strategy [PDF]

, 2010
Background The pig genome is being sequenced and characterised under the auspices of the Swine Genome Sequencing Consortium. The sequencing strategy followed a hybrid approach combining hierarchical shotgun sequencing of BAC clones and whole genome ...
Fredholm, M., Harlizius Barbara, Martien A M Groenen, Bolund, Lars, Rothschild Max F, Lee Kyung-Tai, Jane Rogers, Barbara Harlizius, Denis Milan, Groenen, M.A.M., Lee, Kyung-Tai, ?, ?, Uenishi, Hirohide, Jun Wang, Uenishi Hirohide, Churcher, C., Harlizius, Barbara, Lars Bolund, Lawrence B Schook, Alan L Archibald, Archibald Alan L, Fredholm, Merete, Groenen, Martien A. M., Schook, Lawrence B., Harlizius, B., Fredholm Merete, Archibald, A.L., The Swine Genome Sequencing Consortium,, Milan Denis, Bolund Lars, Groenen, Martien A.M., Rogers Jane, Wang Jun, Swine Genome Sequencing Consortium, Hirohide Uenishi, Groenen Martien AM, Rothschild, Max F., Bolund, L., Milan, Denis, Archibald, Alan L., Wang, Jun, Merete Fredholm, Kyung-Tai Lee, The Swine Genome Sequencing Consortium, -, Carol Churcher, Rogers, Jane, Churcher, Carol, Max F Rothschild, Schook Lawrence B, Churcher Carol   +49 more
core   +1 more source

Comparison of gene fusion detection algorithms reveals frequently overlooked driver fusions in hematologic malignancies

npj Precision Oncology
Accurate detection of driver gene fusions is essential for the diagnosis, treatment, and prognostic prediction of hematologic malignancies. Despite increasing reliance on RNA sequencing (RNA-seq) for fusion detection, its algorithms have not been ...
Zen Tamura, Yuki Saito, Yasunori Kogure, Yuji Oshikawa-Kumade, Suguru Fukuhara, Sumito Shingaki, Hirokazu Kariyazono, Yoshiya Kikukawa, Yuta Ito, Kota Mizuno, Yuichi Shiraishi, Kotoe Katayama, Seiya Imoto, Koji Izutsu, Koichi Murakami, Junji Koya, Keisuke Kataoka   +16 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Sequence analysis and genomic organization of Aphid lethal paralysis virus: a new member of the family Dicistroviridae

, 2002
The complete nucleotide sequence of the genomic RNA of an aphid-infecting virus, Aphid lethal paralysis virus (ALPV), has been determined. The genome is 9812 nt in length and contains two long open reading frames (ORFs), which are separated by an ...
Dullemans, A.M., Verbeek, M., Wilk, F., van der, Heuvel, J.F.J.M., van den, Munster, M., van, Clerivet, A.   +5 more
core  

AGenDA: gene prediction by cross-species sequence comparison

, 2004
Taher L, Rinner O, Garg S, Sczyrba A, Morgenstern B. AGenDA: gene prediction by cross-species sequence comparison. Nucleic Acids Research. 2004;32(Web Server):W305-W308.Automatic gene prediction is one of the major challenges in computational sequence ...
Sczyrba, Alexander ; https://orcid.org/, Garg, S, Garg, S., Sczyrba, A., Taher, L, Rinner, O, Morgenstern, B, Taher, L., Rinner, O., Morgenstern, Burkhard   +9 more
core   +1 more source

GeneQuiz: a workbench for sequence analysis.

Proceedings. International Conference on Intelligent Systems for Molecular Biology, 1994
We present the prototype of a software system, called GeneQuiz, for large-scale biological sequence analysis. The system was designed to meet the needs that arise in computational sequence analysis and our past experience with the analysis of 171 protein sequences of yeast chromosome III.
Scharf, M., SCHNEIDER, Reinhard, Casari, G., Bork, P., Valencia, A., Ouzounis, C., Sander, C.   +6 more
openaire   +3 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi. [PDF]

, 2011
BACKGROUND: Multilocus sequence typing (MLST) is a powerful and highly discriminatory method for analysing pathogen population structure and epidemiology. Trypanosoma cruzi, the protozoan agent of American trypanosomiasis (Chagas disease), has remarkable
Michael A. Miles, Acosta , N,, Llewellyn Martin S., Nidia Acosta, Louisa A Messenger, Acosta Nidia, Bhattacharyya Tapan, Carrasco, Hernan J, Yeo, Matthew, Hernan J Carrasco, Bhattacharyya , T,, Miles, Michael A., Llewellyn , MS,, Isabel L. Mauricio, Yeo Matthew, Miles, M.A., Michael D Lewis, Messenger, Louisa A, Yeo, M., Acosta, N., Mauricio, Isabel Larguinho, Matthew Yeo, Patricio Diosque, Llewellyn, Martin S, Martin S Llewellyn, Miles, Michael A, Lewis, M.D., Messenger Louisa A., Diosque, P., Lewis, Michael D, Miles , MA., Carrasco Hernan J., Llewellyn, Martin S., Llewellyn, M.S., Lewis Michael D., Messenger, L.A., Acosta, Nidia, Lewis, Michael D., Carrasco, H.J., Mauricio, I.L., Mauricio, Isabel L., Messenger, Loisa A., Lewis , MD,, Yeo , M,, Michael A Miles, Miles Michael A., Bhattacharyya, Tapan, Louisa A. Messenger, Carrasco , HJ,, Messenger , LA,, Isabel L Mauricio, Bhattacharyya, T., Diosque Patricio, Hernan J. Carrasco, Martin S. Llewellyn, Diosque, Patricio, Michael D. Lewis, Mauricio, Isabel L, Mauricio Isabel L., Diosque , P,, Tapan Bhattacharyya, Carrasco, Hernán J.   +61 more
core   +1 more source