Results 101 to 110 of about 6,472,845 (290)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Morphological evolution in situ: Disk-dominated cluster red sequences at z ~ 1.25

, 2015
We have carried out a joint photometric and structural analysis of red sequence galaxies in four clusters at a mean redshift of z ~ 1.25 using optical and near-IR HST imaging reaching to at least 3 magnitudes fainter than $M^*$.
Bremer, M. N., De Propris, R., Phillipps, S.   +2 more
core   +1 more source

Intricate interactions between fine-scale genetic structure, lifestyle, and dietary habits in the Japanese population

Communications Biology
The fine-scale genetic structure within populations, focusing on demographic histories and migration patterns, has been explored previously. However, limited attention has been paid to understanding how genetic structure influences lifestyle and dietary ...
Yichi Chen, Kotoe Katayama, Sachiko Ishida, Seiya Imoto   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Clustering Multiple Sclerosis Medication Sequence Data with Mixture Markov Chain Analysis with covariates using Multiple Simplex Constrained Optimization Routine (MSiCOR)

, 2022
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that causes neurodegeneration. While disease-modifying therapies (DMTs) reduce inflammatory disease activity and delay worsening disability in MS, there are significantly ...
Abad, Zahra S. H., Cai, Tianxi, Das, Priyam, De, Debsurya, Hou, Jue, Kim, Nicole, Sen, Deborshee, Xia, Zongqi   +7 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Radar HRRP Modeling using Dynamic System for Radar Target Recognition [PDF]

, 2014
High resolution range profile (HRRP) is being known as one of the most powerful tools for radar target recognition. The main problem with range profile for radar target recognition is its sensitivity to aspect angle. To overcome this problem, consecutive
Ajorloo, A., Bastani, M. H., Hadavi, M., Nayebi, M. M.   +3 more
core