Results 81 to 90 of about 27,025,382 (307)

Pig genome sequence - analysis and publication strategy [PDF]

, 2010
Background The pig genome is being sequenced and characterised under the auspices of the Swine Genome Sequencing Consortium. The sequencing strategy followed a hybrid approach combining hierarchical shotgun sequencing of BAC clones and whole genome ...
Fredholm, M., Harlizius Barbara, Martien A M Groenen, Bolund, Lars, Rothschild Max F, Lee Kyung-Tai, Jane Rogers, Barbara Harlizius, Denis Milan, Groenen, M.A.M., Lee, Kyung-Tai, ?, ?, Uenishi, Hirohide, Jun Wang, Uenishi Hirohide, Churcher, C., Harlizius, Barbara, Lars Bolund, Lawrence B Schook, Alan L Archibald, Archibald Alan L, Fredholm, Merete, Groenen, Martien A. M., Schook, Lawrence B., Harlizius, B., Fredholm Merete, Archibald, A.L., The Swine Genome Sequencing Consortium,, Milan Denis, Bolund Lars, Groenen, Martien A.M., Rogers Jane, Wang Jun, Swine Genome Sequencing Consortium, Hirohide Uenishi, Groenen Martien AM, Rothschild, Max F., Bolund, L., Milan, Denis, Archibald, Alan L., Wang, Jun, Merete Fredholm, Kyung-Tai Lee, The Swine Genome Sequencing Consortium, -, Carol Churcher, Rogers, Jane, Churcher, Carol, Max F Rothschild, Schook Lawrence B, Churcher Carol   +49 more
core   +1 more source

Protective role of the vulture facial skin and gut microbiomes aid adaptation to scavenging

Acta Veterinaria Scandinavica, 2018
Background Vultures have adapted the remarkable ability to feed on carcasses that may contain microorganisms that would be pathogenic to most other animals.
Marie Lisandra Zepeda Mendoza, Michael Roggenbuck, Karla Manzano Vargas, Lars Hestbjerg Hansen, Søren Brunak, M. Thomas P. Gilbert, Thomas Sicheritz-Pontén   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Selection of vaccine-candidate peptides from Mycobacterium avium subsp. paratuberculosis by in silico prediction, in vitro T-cell line proliferation, and in vivo immunogenicity

Frontiers in Immunology
Mycobacterium avium subspecies paratuberculosis (MAP) is a global concern in modern livestock production worldwide. The available vaccines against paratuberculosis do not offer optimal protection and interfere with the diagnosis of bovine tuberculosis ...
Kari Lybeck, Stig Tollefsen, Heidi Mikkelsen, Siri Kulberg Sjurseth, Claus Lundegaard, Claus Aagaard, Ingrid Olsen, Gregers Jungersen   +7 more
doaj   +1 more source

Impact of the rumen microbiome on milk fatty acid composition of Holstein cattle

Genetics Selection Evolution, 2019
Background Fatty acids (FA) in bovine milk derive through body mobilization, de novo synthesis or from the feed via the blood stream. To be able to digest feedstuff, the cow depends on its rumen microbiome. The relative abundance of the microbes has been
Bart Buitenhuis, Jan Lassen, Samantha Joan Noel, Damian R. Plichta, Peter Sørensen, Gareth F. Difford, Nina A. Poulsen   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

BIOINFORMATICS APPLICATIONS NOTE doi:10.1093/bioinformatics/btl007 Sequence analysis

, 2008
Motivation: The first version of the graphical multiple sequence alignment environment QAlign was published in 2003. Heavy response from the molecular-biological user community clearly demonstrated the need for such a platform.
Jens Stoye, Thasso Griebel, Michael Sammeth, Felix Tille, Sequence Analysis   +4 more
core  

Cloning and analysis sequence of Bacillus thuringiensis ENTOMOCIDUS INA 288

, 2020
B. thuringiensis has been studied worldwide over the past decades, mainly because this gram-positive bacterium produces significant amounts of crystal protein toxic activity against economically important insect larvae. Most strains of B. thuringiensis
RIZALI, AKHMAD
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source