Results 91 to 100 of about 3,077,972 (305)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Predictions of the dimerization and autoproteolysis using sequence profile analysis
, 2009 [[abstract]]Protein fold recognition using sequence profile searches frequently allows prediction of the structure and biochemical mechanisms of proteins with an important biological function but unknown biochemical activity. In this present, we describe
Ping-Hsi Liao(廖平喜); Te-Hsiang Chen(陳德祥);Shang-Fang Lee(李尚凡);Pei-Yu Liao(廖珮妤)
core
Patterns of Healthy Aging and Household Size Dynamics in Western Europe
Мониторинг общественного мнения: экономические и социальные перемены, 2020 The diversity of family structures and the quality of social relationships are closely tied to one another. Individual characteristics such as parenting, grandparenting, partnership, cohabitation, living apart together, living solo and other contextual ...
Валентина Ивановна Шиповская
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Propositionalisation of multiple sequence alignments using probabilistic models
, 2008 Multiple sequence alignments play a central role in Bioinformatics. Most alignment representations are designed to facilitate knowledge extraction by human experts.
Mutter, Stefan +2 more
core
, 2022 Police officers’ use of lethal force is scrutinized to determine the appropriateness of the decision to shoot. However, surprisingly little research has systematically examined the sequence of behaviors that leads to this decision.
Porter, Louise E
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Multilocus sequence typing breathes life into a microbial metagenome [PDF]
, 2006 Shot-gun sequencing of DNA isolated from the environment and the assembly of metagenomes from the resulting data has considerably advanced the study of microbial diversity.
Vandamme Peter +23 more
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
JCRPE, 2020 Objective:SHOX gene mutations constitute one of the genetic causes of short stature. The clinical phenotype includes variable degrees of growth impairment, such as Langer mesomelic dysplasia (LMD), Léri-Weill dyschondrosteosis (LWD) or idiopathic short ...
Semra Gürsoy +7 more
doaj +1 more source