Results 71 to 80 of about 2,556,924 (316)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Entropy, 2019 Composite structures undergo a gradual damage evolution from initial inter-fibre cracks to extended damage up to failure. However, most composites could remain in service despite the existence of damage. Prerequisite for a service extension is a reliable
Angelos Filippatos +3 more
doaj +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Non-Linear Dynamics Analysis of Protein Sequences. Application to CYP450
Entropy, 2019 The nature of changes involved in crossed-sequence scale and inner-sequence scale is very challenging in protein biology. This study is a new attempt to assess with a phenomenological approach the non-stationary and nonlinear fluctuation of changes ...
Xavier F. Cadet +3 more
doaj +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
TASK ANALYSIS IN CURRICULUM DESIGN: A HIERARCHICALLY SEQUENCED INTRODUCTORY MATHEMATICS CURRICULUM1 [PDF]
, 1973 Lauren Β. Resnick +2 more
openalex +2 more sources
Inferring joint sequence-structural determinants of protein functional specificity
eLife, 2018 Residues responsible for allostery, cooperativity, and other subtle but functionally important interactions remain difficult to detect. To aid such detection, we employ statistical inference based on the assumption that residues distinguishing a protein ...
Andrew F Neuwald +2 more
doaj +1 more source
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
Learning protein constitutive motifs from sequence data
eLife, 2019 Statistical analysis of evolutionary-related protein sequences provides information about their structure, function, and history. We show that Restricted Boltzmann Machines (RBM), designed to learn complex high-dimensional data and their statistical ...
Jérôme Tubiana +2 more
doaj +1 more source