Results 151 to 160 of about 2,264,396 (196)

Genome annotation: from sequence to biology

Nature Reviews Genetics, 2001
The genome sequence of an organism is an information resource unlike any that biologists have previously had access to. But the value of the genome is only as good as its annotation. It is the annotation that bridges the gap from the sequence to the biology of the organism.
Lincoln Stein
exaly   +3 more sources

Evolutionary sequences in mammalian reproductive biology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, 2020
AbstractBroad biological aspects and accepted evolutionary sequences may offer useful guidance towards a comprehensive explanation of the function of mammalian ovaries and oviducts and their vital contribution to the events of fertilization. Cooling of the preovulatory follicles before ovulation may well have its roots in the primitive stages of ...
Ronald H. F. Hunter, Fernando López‐Gatius   +1 more
openaire   +2 more sources

Comparative biology: beyond sequence analysis

Current Opinion in Biotechnology, 2007
Comparative analysis is a fundamental tool in biology. Conservation among species greatly assists the detection and characterization of functional elements, whereas inter-species differences are probably the best indicators of biological adaptation. Traditionally, comparative approaches were applied to the analysis of genomic sequences.
Itay, Tirosh, Yonatan, Bilu, Naama, Barkai   +2 more
openaire   +2 more sources

Structural biology of metal-binding sequences

Current Opinion in Chemical Biology, 2002
NMR spectroscopy and X-ray crystallography in conjunction with extended X-ray absorption fine structure spectroscopy, have contributed to the elucidation of the structural biology of protein-mediated mechanisms of heavy metal homeostasis. Among the most striking aspects of these investigations are the remarkable similarity of metal-ion-transport and ...
Stanley J, Opella, Tara M, DeSilva, Gianluigi, Veglia   +2 more
openaire   +2 more sources

A Sequence for Biology Studies

Science, 1966
As another parent of two children who have bad high school biology (both had the Biological Sciences Curriculum Study Blue Version course), I would like to comment on Branson's letter (28 Oct.). My children have both come away, instilled with enthusiasm for the study of biology, with the feeling that it's a science, that it's understandable ...
openaire   +3 more sources

Next-generation sequencing transforms today's biology

Nature Methods, 2007
A new generation of non-Sanger-based sequencing technologies has delivered on its promise of sequencing DNA at unprecedented speed, thereby enabling impressive scientific achievements and novel biological applications. However, before stepping into the limelight, next-generation sequencing had to overcome the inertia of a field that relied on Sanger ...
openaire   +2 more sources

Potyvirus serology, sequences and biology

1992
Amino acid sequences of the cytoplasmic cylindrical inclusion protein (CIP), large nuclear inclusion protein (NIb), and coat protein (CP) of potyviruses were re-examined in light of reported serological relationships, and correlated with known and deduced biological functions. No obvious correlations were observed between either amino acid sequences or
openaire   +2 more sources

Computer Applications to Molecular Biology: DNA Sequences

2003
Computers have become a necessary tool in all laboratories involved in DNA sequence work. There has been a rapid increase in the amount of DNA sequenced, and the most recent issue of the European Molecular Biology Laboratory (EMBL) Nucleotide Sequence Data Library (release 10, 1987) contains almost 10 million base pairs in almost 9000 entries compared ...
R, Harr, P, Gustafsson
openaire   +2 more sources

Centromeres: Sequences, Structure, and Biology

2012
Although technological advances have continued to change the speed, cost, and number of plant genomes sequenced (see Flagel and Blackman 2012, this volume), parts of genomes remain to be sequenced and explored. Even the best-sequenced plant genomes, including Arabidopsis thaliana and rice, are missing 7–8% of their total genomic information (Kaul et al.
Cory D. Hirsch, Jiming Jiang
openaire   +1 more source

Unified Deep Learning Architecture for Modeling Biology Sequence

IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2018
Prediction of the spatial structure or function of biological macromolecules based on their sequences remains an important challenge in bioinformatics. When modeling biological sequences using traditional sequencing models, long-range interaction, complicated and variable output of labeled structures, and variable length of biological sequences usually
Hongjie Wu, Chengyuan Cao, Xiaoyan Xia, Qiang Lu   +3 more
openaire   +2 more sources