Results 241 to 250 of about 1,220,765 (311)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Analyzing Microsporidia sp. MB from sequence to biology: comprehensive exploration of the genome, protein structures, and functions through extensive bioinformatics analysis

Lilian Mbaisi Ang’ang’o
openalex   +1 more source

ESM-Ezy: a deep learning strategy for the mining of novel multicopper oxidases with superior properties. [PDF]

Nat Commun
Qian H, Wang Y, Zhou X, Gu T, Wang H, Lyu H, Li Z, Li X, Zhou H, Guo C, Yuan F, Wang Y.   +11 more
europepmc   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Dsembler - DNA Assembly Designer: A Tool for Facilitating Assembly of Oligomers. [PDF]

J Microbiol Biotechnol
Gupta A, Park G, Park SY, Kim H, Rha E, Lee DH, Lee SG, Kim H.   +7 more
europepmc   +1 more source

Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis

Molecular Oncology, EarlyView.
Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger, Dorin Bar‐Ziv, Harriet Kluger   +2 more
wiley   +1 more source

Leveraging Pre-trained AI Models for Robust Promoter Sequence Design in Synthetic Biology

Gui Yang, Yijie Chen, Qinghua Guo, Xinyang Li, Zhen Zhou   +4 more
openalex   +1 more source

Erratum to ?Sequence variability in the fibroin-H intron of domesticated and wild silk moths? 6Insect Biochemistry and Molecular Biology 34 (2004) 343?3529

, 2004
R HERRERA
openalex   +1 more source

Diversification, loss, and virulence gains of the major effector AvrStb6 during continental spread of the wheat pathogen Zymoseptoria tritici. [PDF]

PLoS Pathog
Sampaio AM, Tralamazza SM, Mohamadi F, De Oliveira Y, Enjalbert J, Saintenac C, Croll D.   +6 more
europepmc   +1 more source