Results 71 to 80 of about 3,076,868 (292)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Research on Assembly Sequence Planning of Large Cruise Ship Cabins Based on Improved Genetic Algorithm

Biomimetics
In the construction process of large cruise ships, there are numerous cabin components, and the number of assembly sequences will experience a “combinatorial explosion”, which will become a complex NP hard problem.
Liyang Ju, Xiaoyuan Wu, Yixi Zhao, Jianfeng Liu, Kun Liu   +4 more
doaj   +1 more source

Spectral Method of Measuring of Changes in Time Intervals between Periodic Pulse Sequences

Приборы и методы измерений, 2019
Methods of measuring delay time between periodic sequences of pulses are mostly based on the considered parameter direct measurement. The main disadvantage of this approach is the difficulty of ensuring the measurements accuracy in the noise conditions ...
A. A. Sheinikov, A. V. Isaev, V. V. Zelenko, Yu. V. Sukhodolov   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

High-dimensional change-point detection with sparse alternatives

, 2013
We consider the problem of detecting a change in mean in a sequence of Gaussian vectors. Under the alternative hypothesis, the change occurs only in some subset of the components of the vector.
Enikeeva, Farida, Harchaoui, Zaid
core   +1 more source

On a class of optimization-based robust estimators

, 2017
We consider in this paper the problem of estimating a parameter matrix from observations which are affected by two types of noise components: (i) a sparse noise sequence which, whenever nonzero can have arbitrarily large amplitude (ii) and a dense and ...
Bako, Laurent
core   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Expanding the Scope: Modified Fortescue Theory for Frequency Unbalance Resolution in Control Strategies

Mathematics
To analyze unbalanced electrical systems, the mathematical technique “symmetrical components method” developed by Charles LeGeyt Fortescue in the early 20th century has been very successful in this field.
Karim Mansouri, Brahim Metoui, Cristian Nichita, Amr Yousef, Ezzeddine Touti   +4 more
doaj   +1 more source