Beyond Variant Evolution: Structurally and Functionally Conserved Regions in the 5′UTR of SARS-CoV-2 as Resilient Antiviral Targets [PDF]
BiomedicinesBackground: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense RNA virus, and its genome includes a highly conserved 5′ untranslated region (5′UTR).
Andrea Masotti
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Mth10b, a unique member of the Sac10b family, does not bind nucleic acid. [PDF]
PLoS ONE, 2011 The Sac10b protein family is regarded as a group of nucleic acid-binding proteins that are highly conserved and widely distributed within archaea. All reported members of this family are basic proteins that exist as homodimers in solution and bind to DNA
Yan-Feng Liu +5 more
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Microorganisms, 2021 SARS-CoV-2, the cause of COVID-19, is a new, highly pathogenic coronavirus, which is the third coronavirus to emerge in the past 2 decades and the first to become a global pandemic.
Oluwatoyin Areo +4 more
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Advances in the application of CRISPR-Cas technology in rapid detection of pathogen nucleic acid
Frontiers in Molecular Biosciences, 2023 Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) are widely used as gene editing tools in biology, microbiology, and other fields.
Xiaoping Li +18 more
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mSphere, 2020 In numerous instances, tracking the biological significance of a nucleic acid sequence can be augmented through the identification of environmental niches in which the sequence of interest is present.
Lamia Wahba +6 more
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iCDA-CGR: Identification of circRNA-disease associations based on Chaos Game Representation.
PLoS Computational Biology, 2020 Found in recent research, tumor cell invasion, proliferation, or other biological processes are controlled by circular RNA. Understanding the association between circRNAs and diseases is an important way to explore the pathogenesis of complex diseases ...
Kai Zheng +5 more
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Detection of Bacillus anthracis DNA in complex soil and air samples using next-generation sequencing. [PDF]
PLoS ONE, 2013 Bacillus anthracis is the potentially lethal etiologic agent of anthrax disease, and is a significant concern in the realm of biodefense. One of the cornerstones of an effective biodefense strategy is the ability to detect infectious agents with a high ...
Nicholas A Be +9 more
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C-terminal substitution of HBV core proteins with those from DHBV reveals that arginine-rich 167RRRSQSPRR175 domain is critical for HBV replication. [PDF]
PLoS ONE, 2012 To investigate the contributions of carboxyl-terminal nucleic acid binding domain of HBV core (C) protein for hepatitis B virus (HBV) replication, chimeric HBV C proteins were generated by substituting varying lengths of the carboxyl-terminus of duck ...
Jaesung Jung +8 more
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Zhongguo gonggong weisheng, 2022 ObjectiveTo conduct a gene tracing-based analysis on a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive oropharyngeal swab specimen from a suspected coronavirus disease 2019 (COVID-19) case without epidemiologically-confirmed ...
Wen-jun XIE, Heng CHEN, Jing FENG
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Why do sequence signatures predict enzyme mechanism? Homology versus Chemistry [PDF]
, 2015 We identify, firstly, InterPro sequence signatures representing evolutionary relatedness and, secondly, signatures identifying specific chemical machinery.
De Ferrari, Luna; id_orcid +5 more
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