Results 141 to 150 of about 660,133 (262)

Field-theoretic density estimation for biological sequence space with applications to 5' splice site diversity and aneuploidy in cancer. [PDF]

Proc Natl Acad Sci U S A, 2021
Chen WC, Zhou J, Sheltzer JM, Kinney JB, McCandlish DM.   +4 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Descent from a common ancestor restricts exploration of protein sequence space. [PDF]

Proc Natl Acad Sci U S A
Isakova LH, Streltsova E, Bochkareva OO, Vlasov PK, Kondrashov FA.   +4 more
europepmc   +1 more source

In Silico Identification of Potential Sites for a Plastic-Degrading Enzyme by a Reverse Screening through the Protein Sequence Space and Molecular Dynamics Simulations. [PDF]

Molecules, 2022
Charupanit K, Tipmanee V, Sutthibutpong T, Limsakul P.   +3 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models. [PDF]

Nucleic Acids Res, 2022
Varadi M, Anyango S, Deshpande M, Nair S, Natassia C, Yordanova G, Yuan D, Stroe O, Wood G, Laydon A, Žídek A, Green T, Tunyasuvunakool K, Petersen S, Jumper J, Clancy E, Green R, Vora A, Lutfi M, Figurnov M, Cowie A, Hobbs N, Kohli P, Kleywegt G, Birney E, Hassabis D, Velankar S.   +26 more
europepmc   +1 more source

MODULARED SEQUENCE SPACES

Hokkaido Mathematical Journal, 1954
openaire   +3 more sources

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Design of proteins by parallel tempering in the sequence space. [PDF]

Protein Sci
Kalani P, Spiwok V.
europepmc   +1 more source

Multiobjective heuristic algorithm for <i>de novo</i> protein design in a quantified continuous sequence space. [PDF]

Comput Struct Biotechnol J, 2021
Li RX, Zhang NN, Wu B, OuYang B, Shen HB.   +4 more
europepmc   +1 more source