Results 61 to 70 of about 5,621,799 (250)
Space and sequence: a topography of "here"
Umjetnost Riječi, 2022 Richard McGuire’s Here, an “artist book disguised as a graphic novel”, follows a single viewpoint over a multimillenial timespan. Pursuing potential storylines on several apparently incompatible levels (gestural, historical, evolutionary, cosmic), this ...
Luka Bekavac
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Functional Sequence in Norm Space
Formalized Mathematics, 2020 Summary In this article, we formalize in Mizar [1], [2] functional sequences and basic operations on functional sequences in norm space based on [5]. In the first section, we define functional sequence in norm space. In the second section, we define pointwise convergence and prove some related theorems.
openaire +3 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The scale-free nature of protein sequence space. [PDF]
PLoS ONE, 2018 The sequence space of five protein superfamilies was investigated by constructing sequence networks. The nodes represent individual sequences, and two nodes are connected by an edge if the global sequence identity of two sequences exceeds a threshold ...
Patrick C F Buchholz +2 more
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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Epistasis facilitates functional evolution in an ancient transcription factor
eLifeA protein’s genetic architecture – the set of causal rules by which its sequence produces its functions – also determines its possible evolutionary trajectories.
Brian PH Metzger +3 more
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Statistical extension of bounded sequence space
, 2021 In this paper by using natural density real valued bounded sequence space l ∞ is extented and statistical bounded sequence space l s t ∞ is obtained.
Kaya, Umutcan +2 more
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Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source