Results 81 to 90 of about 660,133 (262)

On Some Properties of New Paranormed Sequence Space of Nonabsolute Type

open access: yesAbstract and Applied Analysis, 2012
We introduce some new generalized sequence space related to the space ℓ(𝑝). Furthermore we investigate some topological properties as the completeness, the isomorphism, and also we give some inclusion relations between this sequence space and some of the
Vatan Karakaya, Necip Şimşek
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

On r-duals of some difference sequence spaces [PDF]

open access: yesMaejo International Journal of Science and Technology, 2013
In this paper we introduce and examine some properties of the sequence spaces C(mv, ,), C(mv, ,, C(mv, ,), Cmv, , and V(mv, ,), and compute the rα-, rβ- and r-duals of the sequence spaces ℓ(v), c(v) and c0(v), and the
Yavuz Altin, Mikail Et, Mahmut Isik
doaj  

The Semi-Difference Entire Sequence Space 𝑐𝑠∩𝑑1

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2011
Let Γ denote the space of all entire sequences. Let Λ denote the space of all analytic sequences. In this paper, we introduce a new class of sequence space, namely, the semi-difference entire sequence space 𝑐𝑠∩𝑑1. It is shown that the intersection of all
N. Subramanian   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Relation of Morrey Sequence Spaces, Weak Type Morrey Sequence Spaces, and Sequence Spaces

open access: yesJurnal Matematika MANTIK, 2022
Pragasto Aji Hendro Puadi   +2 more
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

open access: yesMolecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver   +2 more
wiley   +1 more source

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