Results 71 to 80 of about 660,133 (262)
On Motzkin sequence spaces via q-analog and compact operators
Demonstratio MathematicaWe aim to develop a qq-analog of recently introduced Motzkin sequence spaces by Erdem et al. [Motzkin sequence spaces and Motzkin core, Numer. Funct. Anal. Optim. 45 (2024), no.
Yaying Taja, Mursaleen Mohammad
doaj +1 more source
Epistasis facilitates functional evolution in an ancient transcription factor
eLifeA protein’s genetic architecture – the set of causal rules by which its sequence produces its functions – also determines its possible evolutionary trajectories.
Brian PH Metzger +3 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Characterization of triple χ3 sequence spaces via Orlicz functions [PDF]
Mathematica Moravica, 2016 In this paper we study of the characterization and general properties of triple gai sequence via Orlicz space of χ3 M of χ3 establishing some inclusion relations.
Subramanian N., Esi A.
doaj
Orlicz-Garling sequence spaces of difference operator and their domination in Orlicz-Lorentz spaces
Journal of Inequalities and Applications, 2018 We introduce new classes of generalized Orlicz-Garling sequences and Orlicz-Lorentz sequences by using a sequence of Orlicz functions and difference operator.
Charu Sharma +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
On the sequence space defined by a sequence of moduli and on the rate-spaces
Acta et Commentationes Universitatis Tartuensis de Mathematica, 1996 This article contains no abstract.
openaire +2 more sources
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source