Results 181 to 190 of about 6,337,317 (349)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Humanizing Antibodies and Nanobodies From Scratch With HuDiff. [PDF]

Bio Protoc
Nan Y, Sun H, Zhang B, Yang Y, He J, Bai Q.   +5 more
europepmc   +1 more source

Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample

Proceedings of the National Academy of Sciences of the United States of America, 2010
J. Caporaso, Christian L. Lauber, William Walters, Donna berg-Lyons, C. Lozupone, P. Turnbaugh, N. Fierer, R. Knight   +7 more
semanticscholar   +1 more source

Newton, Fermat, and Exactly Realizable Sequences

, 2013
[[abstract]]In this note, we study intimate relations among the Newton, Fermat and exactly realizable sequences, which are derived from Newton's identities, Fermat's congruence identities, and numbers of periodic points for dynamical systems ...
Du, Bau-Sen; Huang, Sen-Shan; Li, Ming-Chia, Du, Bau-Sen;Huang, Sen-Shan;Li, Ming-Chia   +1 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Morse Sequences

We introduce the notion of a Morse sequence, which provides a simple and effective approach to discrete Morse theory. A Morse sequence is a sequence composed solely of two elementary operations, that is, expansions (the inverse of a collapse), and fillings (the inverse of a perforation).
openaire   +3 more sources

Analyzing and Visualizing State Sequences in R with TraMineR [PDF]

This article describes the many capabilities offered by the TraMineR toolbox for categorical sequence data. It focuses more specifically on the analysis and rendering of state sequences.
Matthias Studer, Gilbert Ritschard, Nicolas S Müller, Alexis Gabadinho   +3 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A unified framework for potency-oriented AMP discovery via multi-modal learning and guided sequence synthesis. [PDF]

PLoS Comput Biol
Zhang W, Wang Y, Zhai Y, Zhang P, Ding Y, Zou Q.   +5 more
europepmc   +1 more source