Results 191 to 200 of about 6,337,317 (349)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

Journal of the American Society for Mass Spectrometry, 1994
J. Eng, A. L. Mccormack, J. Yates
semanticscholar   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

طریقة مقترحة لتقلیل معدل الانسیابیة ومعدل التأخیر فی مسائل المتتابعات

Al-Rafidain Journal of Computer Sciences and Mathematics, 2010
Ghazwan H. Mahmoud
doaj   +1 more source

Predictive design of tissue-specific mammalian enhancers that function in the mouse embryo. [PDF]

Nat Genet
Chen S, Loubiere V, Hollingsworth EW, Murakami K, Mandlburger N, Jacinto SH, Dizehchi A, Schreiber J, Kvon EZ, Stark A.   +9 more
europepmc   +1 more source

PlantCARE, a database of plant cis-acting regulatory elements and a portal to tools for in silico analysis of promoter sequences

Nucleic Acids Res., 2002
M. Lescot, P. Déhais, G. Thijs, K. Marchal, Y. Moreau, Y. Van de Peer, P. Rouzé, S. Rombauts   +7 more
semanticscholar   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Emergence of Oropouche Virus, Venezuela, 2025. [PDF]

Emerg Infect Dis
D'Angelo P, Rodríguez L, Alarcón V, Sulbarán Y, García N, Antonelli G, Aguilar M, Bravo M, Moros ZC, Loureiro CL, Liprandi F, Zambrano JL, Jaspe RC, Pujol FH.   +13 more
europepmc   +1 more source

Morse Sequences on Stacks and Flooding Sequences

This paper builds upon the framework of \emph{Morse sequences}, a simple and effective approach to discrete Morse theory. A Morse sequence on a simplicial complex consists of a sequence of nested subcomplexes generated by expansions and fillings-two operations originally introduced by Whitehead.
openaire   +5 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source