Results 91 to 100 of about 17,798 (304)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Data Driven Surrogate Based Optimization in the Problem Solving Environment WBCSim

, 2009
Large scale, multidisciplinary, engineering designs are always difficult due to the complexity and dimensionality of these problems. Direct coupling between the analysis codes and the optimization routines can be prohibitively time consuming due to the ...
Kamke, F. A., L. T. Watson, Deshpande, S., J. Shu, N. Ramakrishnan, Shu, J., F. A. Kamke, S. Deshpande, Ramakrishnan, N., Watson, L.T.   +9 more
core   +1 more source

Improved sequential optimization method for high dimensional electromagnetic device optimization [PDF]

, 2009
Improved sequential optimization method (SOM) and dimension reduction optimization method (DROM) are presented for high dimensional optimization design problems of electromagnetic devices.
Lei, G, Zhu, J, Shao, KR, Lavers, JD, Guo, Y   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Suboptimal solutions to network team optimization problems

, 2009
Smoothness of the solutions to network team optimization problems with statistical information structure is investigated. Suboptimal solutions expressed as linear combinations of elements from sets of basis functions containing adjustable parameters are ...
Gnecco, Giorgio, Sanguineti, Marcello
core  

Sequential multi-objective optimization method for electromagnetic inverse problems

, 2017
© 2017 IEEE. Sequential multiobjective optimization method based on radial basis function model is presented in this work to deal with the multiobjective design and optimization problems of engineering electromagnetic devices. Firstly, the initial sample
Lei He, Chen, J, Zhang, AJ, Yanbin Li, Gang Lei, Jinhuan Chen, Li, Y, Aijun Zhang, Lei, G, He, L   +9 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

On diagonal QP subproblems for sequential approximate optimization

, 2020
Sequential approximate optimization (SAO) methods aimed at structural optimization often use reciprocal-like approximations in a dual setting; the method of moving asymptotes (MMA) and CONLIN are important and telling examples.

core  

Optimized design of electric shovel working device structure based on BLISCO framework

Jixie qiangdu
In order to find a design solution that meets all the performance requirements while enabling the minimal trade-offs between different objectives, the bi-level integrated system collaborative optization (BLISCO) method based on approximate models is ...
WANG Xin, WU Juan
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source