Results 71 to 80 of about 18,713 (263)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A Generalized SDP Multi-Objective Optimization Method for EM-Based Microwave Device Design

Sensors, 2019
In this article, a generalized sequential domain patching (GSDP) method for efficient multi-objective optimization based on electromagnetics (EM) simulation is proposed.
Ying Liu, Qingsha S. Cheng, Slawomir Koziel   +2 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Preventive-Corrective Control for Static Voltage Stability Under Multiple $N-1$ Contingencies Considering Wind Power Uncertainty

CSEE Journal of Power and Energy Systems
An optimal preventive-corrective control model for static voltage stability under multiple $N-1$ contingencies considering the wind power uncertainty is established in this paper.
Yuerong Yang, Shunjiang Lin, Qiong Wang, Mingbo Liu, Qifeng Li   +4 more
doaj   +1 more source

Design optimization of variable blank holder force trajectory and blank shape for S-rail shaped product using a novel springback evaluation

Nihon Kikai Gakkai ronbunshu, 2018
High strength steel (HSS) have several advantages such as lightweight and high shock absorption. In sheet metal forming of HSS, twist springback occurs remarkably, which results in the low product quality. In addition, major defects such as wrinkling and
Masaki YOKOYAMA, Ryoto ISHIZUKI, Satoshi KITAYAMA, Kiichiro KAWAMOTO, Shinji NATSUME, Kazuaki ADACHI, Takahiro NOGUCHI, Toshio OHTANI   +7 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Optimized design of electric shovel working device structure based on BLISCO framework

Jixie qiangdu
In order to find a design solution that meets all the performance requirements while enabling the minimal trade-offs between different objectives, the bi-level integrated system collaborative optization (BLISCO) method based on approximate models is ...
WANG Xin, WU Juan
doaj  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Multi-objective optimization for multi-layer microperforated panel sound absorber in a random incidence field

Nihon Kikai Gakkai ronbunshu
Micro-perforated panel absorbers (MPPA) are sound-absorbing materials based on Helmholtz resonance, consisting of a perforated panel with sub-millimeter holes backed by an air cavity.
Satoshi TABUCHI, Satoshi KITAYAMA
doaj   +1 more source