Results 81 to 90 of about 17,798 (304)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

An adjoint for likelihood maximization

, 2009
The process of likelihood maximization can be found in many different areas of computational modelling. However, the construction of such models via likelihood maximization requires the solution of a difficult multi-modal optimization problem involving ...
Bressloff, Neil W., Andy J. Keane, Keane, Andy J., Holden, Carren, Alexander I J Forrester, Neil W Bressloff, Carren Holden, Forrester, Alexander I.J., Toal, David J.J.   +8 more
core   +1 more source

A Generalized SDP Multi-Objective Optimization Method for EM-Based Microwave Device Design

Sensors, 2019
In this article, a generalized sequential domain patching (GSDP) method for efficient multi-objective optimization based on electromagnetics (EM) simulation is proposed.
Ying Liu, Qingsha S. Cheng, Slawomir Koziel   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

AIAA-2002-5505 AN INTERIOR POINT SEQUENTIAL APPROXIMATE OPTIMIZATION METHODOLOGY.

, 2008
The use of optimization in a simulation based design environment has become a common trend in industry today. Computer simulation tools are common place in many engineering disciplines, providing the designers with tools to evaluate a design’s ...
Layne T. Watson
core  

Design optimization of variable blank holder force trajectory and blank shape for S-rail shaped product using a novel springback evaluation

Nihon Kikai Gakkai ronbunshu, 2018
High strength steel (HSS) have several advantages such as lightweight and high shock absorption. In sheet metal forming of HSS, twist springback occurs remarkably, which results in the low product quality. In addition, major defects such as wrinkling and
Masaki YOKOYAMA, Ryoto ISHIZUKI, Satoshi KITAYAMA, Kiichiro KAWAMOTO, Shinji NATSUME, Kazuaki ADACHI, Takahiro NOGUCHI, Toshio OHTANI   +7 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Preventive-Corrective Control for Static Voltage Stability Under Multiple $N-1$ Contingencies Considering Wind Power Uncertainty

CSEE Journal of Power and Energy Systems
An optimal preventive-corrective control model for static voltage stability under multiple $N-1$ contingencies considering the wind power uncertainty is established in this paper.
Yuerong Yang, Shunjiang Lin, Qiong Wang, Mingbo Liu, Qifeng Li   +4 more
doaj   +1 more source