Results 61 to 70 of about 163,780 (214)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
On the approximation of some optimal sequential plan [PDF]
Applicationes Mathematicae, 1988 The paper is concerned with the problem of sequential estimating the parameter of the drift coefficient in stochastic diffusion processes and fields. We consider the models when drift is known up to a multiplicative constant. For such models \textit{A. A. Novikov} [Theor. Probab. Appl. 16, 391-393 (1971); translation from Teor. Veroyatn. Primen.
openaire +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2020 As weldline that is formed when two or more flow fronts meet has an influence on not only the appearance but also the strength of a plastic product, it is important to reduce it as much as possible.
Satoshi KITAYAMA +5 more
doaj +1 more source
Compression for Smooth Shape Analysis
, 2016 Most 3D shape analysis methods use triangular meshes to discretize both the shape and functions on it as piecewise linear functions. With this representation, shape analysis requires fine meshes to represent smooth shapes and geometric operators like ...
Estellers, V. +2 more
core +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Dynamic Optimal Control of a One-Dimensional Magnetohydrodynamic System With Bilinear Actuation
IEEE Access, 2018 The manipulation of the magnetic field has been a proven effective method to change the flow velocity in magnetohydrodynamics (MHD) flow systems. In this paper, we consider a novel bilinear magnetic control problem arising in a 1-D MHD flow system ...
Zhigang Ren +3 more
doaj +1 more source