Results 111 to 120 of about 154,271 (296)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Fairness in Multi-Agent Sequential Decision-Making
, 2014 We define a fairness solution criterion for multi-agent decision-making problems, where agents have local interests. This new criterion aims to maximize the worst performance of agents with consideration on the overall performance.
Zhang, Chongjie, Shah, Julie A
core
Sequential fixed width confidence intervals [PDF]
, 2000 We consider the problem of constructing confidence intervals of fixed width d and confidence level γ for the success probability p in Bernoulli trials.
Asparouhov, Tihomir Zlatev
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Optimal Sequential Investigation Rules in Competition Law [PDF]
Although both in US antitrust and European competition law there is a clear evolution to a much broader application of "rule of reason" (instead of per-se rules), there is also an increasing awareness of the problems of a case-by-case approach.
Jürgen-Peter Kretschmer +2 more
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Smart Learning EnvironmentsLearning engagement is inherently dynamic, historically dependent, and oriented to long-term utility. Building on sequential decision-making theory, this study simulates the dynamic, long-term evolution of online learning engagement among Chinese EFL ...
Hong Xie
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Analysis and Intuition in Strategic Decision Making the Case of California [PDF]
, 2006 This paper reports the results of a study that attempts to assess the effects of decision making circumstances focusing mainly on the approaches applied and the managerial skills and capabilities the decision makers built on during concrete strategic ...
Zoltayné Paprika, Zita
core +1 more source
Self-motion perception and sequential decision-making: where are we heading? [PDF]
Philos Trans R Soc Lond B Biol Sci, 2023 Jerjian SJ, Harsch DR, Fetsch CR.
europepmc +1 more source