Results 81 to 90 of about 622,755 (276)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The effect of incentive structure on search in the secretary problem [PDF]

Judgment and Decision Making, 2020
We tested the effectiveness of performance-based incentive structures using three incentive structures --- commission base, best only and flat fee --- and two levels of context --- no context and house-selling --- in an experiment in which participants ...
Yu-Chin Hsiao, Simon Kemp
doaj  

Geometric Multi-Model Fitting by Deep Reinforcement Learning

, 2018
This paper deals with the geometric multi-model fitting from noisy, unstructured point set data (e.g., laser scanned point clouds). We formulate multi-model fitting problem as a sequential decision making process.
Chen, Yiping, Li, Jonathan, Wang, Cheng, Yang, Chenhui, Zeng, Hongbin, Zhang, Zongliang   +5 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Sequential decision making in merger control [PDF]

, 2014
We model merger control procedures as a process of sequential acquisition of information and compare US and EU procedures. In the US, the authorities do not have to justify their decision to require further information (issue a second request), whereas ...
Langus, Gregor, Lipatov, Vilen, Neven, Damien   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Parsing a perceptual decision into a sequence of moments of thought

Frontiers in Integrative Neuroscience, 2011
Theoretical, computational and experimental studies have converged to a model of decision-making in which sensory evidence is stochastically integrated to a threshold, implementing a shift from an analog to a discrete form of computation.
Martin eGraziano, Pablo ePolosecki, Diego Edgar Shalom, Mariano eSigman   +3 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Failing Despite Knowing. Repeated Decision-Making During Binary Random Sequences with Asymmetric Probabilities

Open Psychology
Previous research shows that people often misinterpret randomness, expecting short-term outcomes to balance out, known as negative recency. Most studies have focused on binary events with equal odds (1:1).
Uatkán Ajna, Ruzsa Gábor, Faragó Klára   +2 more
doaj   +1 more source

Value construction through sequential sampling explains serial dependencies in decision making

eLife
Deciding between a pair of familiar items is thought to rely on a comparison of their subjective values. When the values are similar, decisions take longer, and the choice may be inconsistent with stated value.
Ariel Zylberberg, Akram Bakkour, Daphna Shohamy, Michael N Shadlen   +3 more
doaj   +1 more source