Results 101 to 110 of about 136,209 (296)

Deciding when to decide : time-variant sequential sampling models explain the emergence of value-based decisions in the human brain [PDF]

, 2012
The cognitive and neuronal mechanisms of perceptual decision making have been successfully linked to sequential sampling models. These models describe the decision process as a gradual accumulation of sensory evidence over time. The temporal evolution of
Rieskamp, Jörg, Büchel, Christian, Gluth, Sebastian   +2 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Is Specialization Desirable in Committee Decision Making? [PDF]

Committee decision making is examined in this study focusing on the role assigned to the committee members. In particular, we are concerned about the comparison between committee performance under specialization and non-specialization of the decision ...
Winston Koh, Ruth Ben-Yashar, Shmuel Nitzan   +2 more
core  

Measurement and modeling: sequential use of analytical techniques in a study of risk-taking in decision-making by school principals

, 2016
This paper investigates reasoned risk-taking in decision-making by school principals using a methodology that combines sequential use of psychometric and traditional measurement techniques.
Trimmer, Karen
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Decision making with decision event graphs [PDF]

, 2010
We introduce a new modelling representation, the Decision Event Graph (DEG), for asymmetric multistage decision problems. The DEG explicitly encodes conditional independences and has additional significant advantages over other representations of ...
Thwaites, Peter, Smith, J. Q., Cowell, Robert G.   +2 more
core  

Causal Explanations for Sequential Decision Making

Journal of Artificial Intelligence Research
Stochastic sequential decision-making systems — such as Markov decision processes and their variants — are increasingly used in areas such as transportation, healthcare, and communication. However, the ability to explain these systems’ outputs to non-technical end users has not kept pace with their widespread adoption.
Samer B. Nashed, Saaduddin Mahmud, Claudia V. Goldman, Shlomo Zilberstein   +3 more
openaire   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Fairness in Multi-Agent Sequential Decision-Making

, 2014
We define a fairness solution criterion for multi-agent decision-making problems, where agents have local interests. This new criterion aims to maximize the worst performance of agents with consideration on the overall performance.
Zhang, Chongjie, Shah, Julie A
core