Results 71 to 80 of about 540,179 (287)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Direct Instantaneous Frequency Rate Estimation to Improve the Carrier Estimation Performance in Mars Entry, Descent, and Landing Flight

Remote Sensing, 2018
This paper focuses on the carrier estimation performance improvement in Mars entry, descent, and landing (EDL) flights. Carrier reconstruction could be used for trajectory derivation and Martian atmosphere profile inversion, and is the critical ...
Wanhong Hao, Xiaowei Cui, Jianguang Feng, Guangliang Dong, Zhiyong Zhu   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Asymptotic optimality of sequential designs for estimation

International Journal of Mathematics and Mathematical Sciences, 1995
This paper is concerned with the problem of allocating a fixed number of trials between K independent populations from the exponential family, in order to estimate a linear combination of the means with squared error loss.
Kamel Rekab
doaj   +1 more source

Model error and sequential data assimilation. A deterministic formulation

, 2008
Data assimilation schemes are confronted with the presence of model errors arising from the imperfect description of atmospheric dynamics. These errors are usually modeled on the basis of simple assumptions such as bias, white noise, first order Markov ...
Carrassi, A., Nicolis, C., Vannitsem, S.
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Psychophysics and the judgment of price: Judging complex objects on a non-physical dimension elicits sequential effects like those in perceptual tasks

Judgment and Decision Making, 2009
When participants in psychophysical experiments are asked to estimate or identify stimuli which differ on a single physical dimension, their judgments are influenced by the local experimental context — the item presented and judgment made on the previous
William J. Matthews, Neil Stewart
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A deep Koopman operator‐based modelling approach for long‐term prediction of dynamics with pixel‐level measurements

CAAI Transactions on Intelligence Technology
Although previous studies have made some clear leap in learning latent dynamics from high‐dimensional representations, the performances in terms of accuracy and inference time of long‐term model prediction still need to be improved. In this study, a deep
Yongqian Xiao, Zixin Tang, Xin Xu, Xinglong Zhang, Yifei Shi   +4 more
doaj   +1 more source