Results 131 to 140 of about 49,380 (287)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Understanding the roadside behaviour of children with DCD and/or ADHD: An exploratory sequential design study [PDF]

Background Navigating roads safely is a complex task, requiring a high level of perceptual-motor skills including selecting safe crossing sites, perceiving and responding to approaching vehicles, and selecting safe crossing gaps.
Falemban, Rayan
core  

Evaluation of Harezmi Education Model Applications According to Student Opinions: An Exploratory Sequential Mixed Design Research

 Harezmi Education Model (HEM), one of the applications based on an interdisciplinary approach, is an education model that allows students to develop 21st century skills such as algorithmic thinking, problem solving, and working in a team (MEB, 2021)
Çeliköz, Mine, Hastürk, Dilek
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Designs efficiency for nonmarket valuation with choice modelling: how to measure it, what to report and why

, 2007
We review the basic principles for the evaluation of design efficiency in discrete choice modelling with a focus on efficiency of WTP estimates from the multinomial logit model.
Rose, John M., Rose, J. M., Scarpa, R., Scarpa, Riccardo   +3 more
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Formulation of Nursing Process Assessment Tool from students\u27 perception as outcome of exploratory mixed methods

, 2018
This ongoing research project is an exploratory sequential mixed methods design which aims to formulate a Nursing Process Assessment Tool based from the students perceptions.
Ashmauey, Asmaa Abdulhamed, Sauce, Ben Ryan Jucay, Salvador, Jordan Tovera, Al-Omran, Hasan Kamal, Schonewille, May Ann Pacatang, Mohammed, Eman Rashad, Alvarez, Marc Oneel Castillo, Albuhumud, Muktar, Awadh, Lamia Amen, AlElaiw, Kowther Hassan, Alzaid, Mohammed, Rosario, Ahrjhaynes Balanag   +11 more
core  

Design and psychometric testing of a moral intelligence instrument for pre-hospital emergency medical services personnel: a sequential-exploratory mixed-method study

Background Moral intelligence is a significant and influential factor in the delivery of principled and high-quality care. This is because moral intelligence is the ability to recognize and be sensitive to moral issues, which contributes to the ...
Rasoul Salimi, Fateme Mohammadi, Salman Khazaei, Mostafa Bijani   +3 more
core   +1 more source