Results 71 to 80 of about 49,380 (287)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
An Incremental Kriging Method for Sequential Optimal Experimental Design
, 2014 Kriging model, which provides an exact interpolation and minimizes the error estimates, is a highly-precise global approximation model in contrast with other traditional response surfaces. Therefore, sequential exploratory experimental design (SEED) with
Yaohui Li, Yizhong Wu, Zhengdong Huang
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Frontiers in PsychologyIntroductionUnderstanding how students engage with AI-driven feedback remains understudied in educational psychology. With ChatGPT’s emergence as a generative artificial intelligence tool, automated design improvement feedback (ADIF) has expanded ...
Xin Wu +8 more
doaj +1 more source
An Experimental Study of Information Revelation Policies in Sequential Auctions [PDF]
Theoretical models of information asymmetry have identied a tradeoff between the desire to learn and the desire to prevent an opponent from learning private information.
Karthik N. Kannan +2 more
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Codifying distributed cognition: a case study of emergency medical dispatch
, 2004 The theory of distributed cognition is recognised as being relevant to system analysis and design but it has lacked visibility for practice. In this paper I develop a codified method of analysis based on distributed cognition which provides both ...
Furniss, D.
core
An exploratory sequential mixed methods design to determine user-preferred app features
, 2021 : The need for transfusable blood for medical treatments and emergency procedures is constant, and currently blood donation organisations in South Africa are operating with a maximum of two or three days of blood supply. The aim of the research, of which
Rensleigh, Chris, Potgieter, Andrea
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source