Results 71 to 80 of about 44,449 (246)

Exploratory Sequential Analysis on the Factors Affecting the Leadership of Women in Local Governments

Changing Societies & Personalities
Inclusive governance fosters opportunities for women to contribute to societal advancement by serving in government roles. This paper explores the factors influencing women’s leadership within the context of local government.
Ronel Geraldizo Dagohoy, Mervin G. Gascon   +1 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Development and psychometric evaluation of a compassion perception instrument for patients with cancer receiving nursing care: a mixed-methods study protocol

BMJ Open
Introduction Compassion is a core value in person-centred nursing and is essential in the care of patients with cancer. However, existing measurement instruments often fail to capture the cultural, ethical and relational dimensions of compassion as ...
Anoshirvan Kazemnejad, Eesa Mohammadi, Yaser Khanchemehr, Mitra Khoobi   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Critical Thinking in Elementary Mathematics: A mindful, Meaningful, and Joyful Learning Model

Revija za Elementarno Izobraževanje
This study evaluates a deeper learning model integrating mindful, meaningful, and joy-ful learning to bridge the procedural-conceptual knowledge gap.
Pariang Sonang Siregar, Neni Hermita, Firman Santosa, Tety Herti   +3 more
doaj   +1 more source

Factors affecting the sustainability of educational changes: A mixed method research

Cogent Education, 2018
The aim of this study is to determine factors affecting the sustainability of educational changes. With this purpose in mind, exploratory sequential mixed methods design was used. During the first phase of the study, 18 teachers and school administrators
Murat Baglibel, Mustafa Samancioglu, Gary M. Crow   +2 more
doaj   +1 more source

Development of an ecological momentary assessment of fatigue after ABI using sequential exploratory design

, 2020
Background: It is estimated that between 21 -77% people with acquired brain injury (ABI) experience problematic and persistent fatigue. Many struggle to resume their previous levels of activity and participation. Yet the relationship between fatigue and participation is unclear.
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source