Results 81 to 90 of about 49,380 (287)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Development of the Salford rheumatoid arthritis foot evaluation instrument : a sequential exploratory mixed methods design [PDF]
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that commonly manifests in the feet as pain, swelling and deformity. These symptoms often have extensive and severe mutlidimensional consequences for people's lives and can be evaluated using a class of subjective outcome measures known as patient-reported outcome measures (PROMs ...
Walmsley, S
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Provision and accessibility to primary care services for immigrants experiencing homelessness in England: a sequential exploratory mixed method study [PDF]
Background Immigrant communities, like refugees, asylum seekers, and irregular immigrants, encounter unique health challenges, contributing to their suboptimal well-being.
Namata, C.
core
Research Needs and Learning Format Preferences of Graduate Students at a Large Public University: An Exploratory Study [PDF]
, 2017 This article reports on a study of research needs and learning preferences of graduate students at a public research university. A sequential exploratory mixed-method design was used, with a survey instrument developed from an initial qualitative stage ...
Guder, Christopher S. +5 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Use of Mixed Method in Marketing Research: A Content Analysis [PDF]
Interdisciplinary Description of Complex SystemsWhile the integration of qualitative and quantitative research methods has been relatively rare, it has been applied in numerous studies over the years. However, a standardized framework for combining different data collection methods remains elusive. As
Mustafa Polat, Yusuf Öcel
doaj +1 more source
Social determinants of mental health of pregnant women in Nepal: a sequential exploratory mixed methods research study [PDF]
Women during pregnancy are at risk of developing poor mental health, and it is one of the major concerns in low- and middle-income countries, including Nepal.
Sah, L.
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source