Results 81 to 90 of about 1,039,304 (269)
Fast Cross-Validation via Sequential Testing [PDF]
, 2015 With the increasing size of today's data sets, finding the right parameter configuration in model selection via cross-validation can be an extremely time-consuming task.
Braun, Mikio +2 more
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Methods and Approaches for Characterizing Learning Related Changes Observed in functional MRI Data — A Review [PDF]
, 2003 Brain imaging data have so far revealed a wealth of information about neuronal circuits involved in higher mental functions like memory, attention, emotion, language etc. Our efforts are toward understanding the learning related effects in brain activity
Bapi, Raju S. +2 more
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Implementing online interventions in ICare: A biostatistical perspective
Internet Interventions, 2019 The implementation of research studies is a highly complex process. All decisions with respect to the study design impact the statistical analyses and interpretation of the results.
Dennis Görlich, Andreas Faldum
doaj +1 more source
Experimental Design for Sensitivity Analysis, Optimization and Validation of Simulation Models [PDF]
This chapter gives a survey on the use of statistical designs for what-if analysis in simula- tion, including sensitivity analysis, optimization, and validation/verification. Sensitivity analysis is divided into two phases.
Kleijnen, J.P.C.
core +1 more source
Experimental evaluation of confidence interval procedures in sequential steady-state simulation [PDF]
, 1996 Sequential analysis of simulation output is generally accepted as the most efficient way for securing representativeness of samples of collected observations.
Brost, H. +5 more
core
Sequential Bayesian inference for implicit hidden Markov models and current limitations
, 2015 Hidden Markov models can describe time series arising in various fields of science, by treating the data as noisy measurements of an arbitrarily complex Markov process.
Jacob, Pierre E.
core +1 more source