Results 181 to 190 of about 9,529,065 (267)

Structural and Proteomic Analysis of the Mouse Cathepsin B-DARPin 4m3 Complex Reveals Species-Specific Binding Determinants. [PDF]

Int J Mol Sci
Zarić M, Tušar L, Kramer L, Vasiljeva O, Novak M, Impens F, Usenik A, Gevaert K, Turk D, Turk B.   +9 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

[Description of Hip Deformities in 5-Year-Old Patients with Congenital Zika Virus Syndrome]. [PDF]

Rev Bras Ortop (Sao Paulo)
Kleebayoon A, Wiwanitkit V.
europepmc   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Reduction-Responsive Nanoparticles Self-Assembled from Sericin-ss-Doxorubicin Conjugate for Hydrophobic IR780 Delivery with Integration of Antitumor Chemo-Phototherapy. [PDF]

Int J Nanomedicine
Zhang L, Liu H, Ren J, Shao J, Cao Y, Wang S, Peng C, Shao S, Ge H, Yu J.   +9 more
europepmc   +1 more source

An All‐Soft Wearable Electrochemiluminescence Chip for Sweat Metabolite Detection

Advanced Science, EarlyView.
A wearable electrochemiluminescence chip for sweat metabolite monitoring is pioneered, integrating “all‐soft” components: a flexible closed bipolar electrode (c‐BPE) array based on laser‐induced graphene (LIG), a laser‐cut microfluidic layer for sweat collection, and deep eutectic solvents (DES)‐based conductive ionogels for ECL emission.
Wei Nie, Jie Jiang, Xi Wei, Linfeng Zhuo, Danyang Li, Mingyu Jia, Tianhua Zheng, Hua Cui   +7 more
wiley   +1 more source

Serine tRNAs compete to regulate the mRNA translation of serine-sensitive codons. [PDF]

Sci Adv
Costiniti V, Tran WC, Babu NR, Kanshin E, Ueberheide B, Kimmelman AC, Banh RS.   +6 more
europepmc   +1 more source

Atomically Precise Clusterzymes: A Programmable Optoelectronic Platform for Neuroscience

Advanced Science, EarlyView.
Atomically precise clusterzymes, engineered via atomic and ligand design, serve as programmable platforms for neuroscience applications. They demonstrate tailored biocatalysis for neuroinflammation, tunable optical properties for deep‐tissue bioimaging and 3D visualization, and enhanced charge transfer for brain–computer interfaces.
Si Sun, Di Liu, Sufei Zhou, Yang Wang, Hao Wang, Ziliang Zheng, Xiao‐Dong Zhang   +6 more
wiley   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source