Serial crystallography on in vivo grown microcrystals using synchrotron radiation
IUCrJ, 2014 Crystal structure determinations of biological macromolecules are limited by the availability of sufficiently sized crystals and by the fact that crystal quality deteriorates during data collection owing to radiation damage. Exploiting a micrometre-sized
Cornelius Gati +13 more
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Coherence of femtosecond single electrons exceeds biomolecular dimensions
, 2013 Time-resolved diffraction and microscopy with femtosecond electron pulses provide four-dimensional recordings of atomic motion in space and time. However, the limited coherence of electron pulses, reported in the range of 2–3 nm, has so far prevented the
Baum, P. +3 more
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Recent results in time resolved serial femtosecond crystallography at XFELs
Current Opinion in Structural Biology, 2020 Time-resolved serial femtosecond crystallography (tr-SFX) methods exploit slurries of crystalline samples that range in size from hundreds of nanometers to a few tens of micrometers, at near-physiological temperature and pressure, to generate atomic resolution models and probe authentic function with the same experiment. 'Dynamic structural biology' is
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Observations of ultra-fast light-induced processes in proteins using time-resolved serial femtosecond crystallography [PDF]
, 2018 Gabriela Nass Kovács
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Convergent-beam attosecond x-ray crystallography
Structural DynamicsSub-ångström spatial resolution of electron density coupled with sub-femtosecond to few-femtosecond temporal resolution is required to directly observe the dynamics of the electronic structure of a molecule after photoinitiation or some other ultrafast ...
Henry N. Chapman +19 more
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IUCrJ, 2017 Crystal structure determination of biological macromolecules using the novel technique of serial femtosecond crystallography (SFX) is severely limited by the scarcity of X-ray free-electron laser (XFEL) sources. However, recent and future upgrades render
Jose M. Martin-Garcia +29 more
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Review of serial femtosecond crystallography including the COVID-19 pandemic impact and future outlook. [PDF]
Structure, 2023 Botha S, Fromme P.
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Case Study of High-Throughput Drug Screening and Remote Data Collection for SARS-CoV-2 Main Protease by Using Serial Femtosecond X-ray Crystallography [PDF]
, 2021 Ömür Güven +21 more
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Serial Femtosecond Zero Dose Crystallography Captures a Water‐Free Distal Heme Site in a Dye‐Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in FeIV=O Formation [PDF]
, 2020 Marina Lučić +14 more
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Soft x-ray absorption spectroscopy of metalloproteins and high-valent metal-complexes at room temperature using free-electron lasers [PDF]
, 2017 X-ray absorption spectroscopy at the L-edge of 3d transition metals provides unique information on the local metal charge and spin states by directly probing 3d-derived molecular orbitals through 2p-3d transitions.
Agapie, Theodor +5 more
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