Results 161 to 170 of about 136,540 (358)

Multiphysical Field Modulated VO2 Device for Information Encryption. [PDF]

open access: yesAdv Sci (Weinh), 2023
Zhao S   +8 more
europepmc   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A Blueprint for Destruction: Eco-Activism in Doctor Who during the 1970s

open access: yesEcozon@, 2012
This article analyzes the television science-fiction show Doctor Who as a cultural forum within the context of British eco-activism of the 1970s. It examines four serials which aired during the 1970s during the first wave of eco-activism in the UK: "The ...
Dolly Jørgensen
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

A formação de uma biblioteca digital, através dos sumários correntes de periódicos da área educacional: procecimentos, metodologia e acesso on-line de documentos

open access: yesETD: Educação Temática Digital, 2000
O presente trabalho descreve o resultado de uma experiência realizada na Biblioteca da Faculdade de Educação da UNICAMP com o propósito de disponibilizar via acesso Internet, o seu acervo de periódicos, através dos sumários digitalizados, com o intuito ...
Gildenir Carolino Santos   +1 more
doaj  

Penatalaksanaan Anestesi pada Tindakan Bedah Tumor Fossa Posterior: Serial Kasus

open access: gold, 2016
Iwan Abdul Rachman   +3 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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