Results 91 to 100 of about 1,088,700 (412)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Cellular Redox Imbalance and Neurochemical Effect in Cognitive-Deficient Old Rats

Behavioral Sciences, 2018
The purpose of the present study is to access the linkage between dysregulation of glutamatergic neurotransmission, oxidative metabolism, and serine signaling in age-related cognitive decline.
Maria Elena González-Fraguela, Lisette Blanco-Lezcano, Caridad Ivette Fernandez-Verdecia, Teresa Serrano Sanchez, Maria de los A. Robinson Agramonte, Lidia Leonor Cardellá Rosales   +5 more
doaj   +1 more source

2,3-Diaminopropanols Obtained from d-Serine as Intermediates in the Synthesis of Protected 2,3-l-Diaminopropanoic Acid (l-Dap) Methyl Esters

Molecules, 2020
A synthetic strategy for the preparation of two orthogonally protected methyl esters of the non-proteinogenic amino acid 2,3-l-diaminopropanoic acid (l-Dap) was developed. In these structures, the base-labile protecting group 9-fluorenylmethyloxycarbonyl
Andrea Temperini, Donatella Aiello, Fabio Mazzotti, Constantinos M. Athanassopoulos, Pierantonio De Luca, Carlo Siciliano   +5 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

ANODIC OXIDATION OF DIFFERENT IONIC FORMS OF SERINE ON THE Pt(Pt)-ELECTRODE

Конденсированные среды и межфазные границы, 2018
. The task of the work was to establish the infl uence of the charge state serine determined by the pH value of the medium on kinetic regularities and quantitative characteristics of the process of its anodic oxidation on a platinized platinum electrode.
Alexander V. Vvedenskii, Elena V. Bobrinskaya, Nadazhda E. Kuleshova   +2 more
doaj   +1 more source

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

Science, 2018
Mitochondrial serine transporter identified One-carbon (1C) metabolism is a universal metabolic process that is required for purine synthesis and supports the high levels of proliferation in cancer cells.
Nora Kory, Gregory A. Wyant, G. Prakash, Jelmi uit de Bos, Francesca Bottanelli, M. Pacold, Sze Ham Chan, C. Lewis, Tim Wang, Heather R. Keys, Y. Guo, D. Sabatini   +11 more
semanticscholar   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Roles and regulation of membrane-associated serine proteases [PDF]

, 2007
Pericellular proteolytic activity affects many aspects of cellular behaviour, via mechanisms involving processing of the extracellular matrix, growth factors and receptors.
Bass, Rosemary, Ellis, V, Gray, Kelly, Owen, K, Qiu, Deyi   +4 more
core   +1 more source

Enzymatic Phosphorylation of Serine [PDF]

Journal of Biological Chemistry, 1972
Abstract The occurrence of a pyrophosphate:l-serine phosphotransferase in extracts of Propionibacterium shermanii is reported. A 102-fold purification, with 15% recovery, was obtained by successive use of protamine sulfate precipitation, acidification, ammonium sulfate precipitation, and chromatography on DEAE-cellulose and on Bio-Gel P-150 columns ...
Lauren M. Cagen, Herbert C. Friedmann
openaire   +2 more sources

The importance of serine metabolism in cancer

Journal of Cell Biology, 2016
Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells ...
Katherine R. Mattaini, Mark R. Sullivan, M. V. Vander Heiden   +2 more
semanticscholar   +1 more source