Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway
Cells, 2019 Tight regulation of signaling from receptor tyrosine kinases is required for normal cellular functions and uncontrolled signaling can lead to cancer. Fibroblast growth factor receptor 2 (FGFR2) is a receptor tyrosine kinase that induces proliferation and
Patrycja Szybowska +4 more
doaj +1 more source
Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke [PDF]
, 2008 Cigarette smoke (CS)–induced lung inflammation involves the reduction of histone deacetylase 2 (HDAC2) abundance, which is associated with steroid resistance in patients with chronic obstructive pulmonary disease and in individuals with severe asthma who
Adenuga, David +4 more
core +2 more sources
Experimental application of sum rules for electron energy loss magnetic chiral dichroism [PDF]
, 2007 We present a derivation of the orbital and spin sum rules for magnetic circular dichroic spectra measured by electron energy loss spectroscopy in a transmission electron microscope. These sum rules are obtained from the differential cross section calculated for symmetric positions in the diffraction pattern.
arxiv +1 more source
Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut
Nature Microbiology, 2019 Metabolic reprogramming is associated with the adaptation of host cells to the disease environment, such as inflammation and cancer. However, little is known about microbial metabolic reprogramming or the role it plays in regulating the fitness of ...
Sho Kitamoto +25 more
semanticscholar +1 more source
SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. [PDF]
, 2018 BackgroundSerine proteases are important virulence factors for many pathogens. Recently, we discovered a group of trypsin-like serine proteases with domain organization unique to flatworm parasites and containing a thrombospondin type 1 repeat (TSR-1 ...
Caffrey, Conor R +13 more
core +2 more sources
Dual targeting of glutamine and serine metabolism in acute myeloid leukemia
Frontiers in OncologyAcute myeloid leukemia (AML) is a heterogeneous hematological malignancy characterized by disrupted blood cell production and function. Recent investigations have highlighted the potential of targeting glutamine metabolism as a promising therapeutic ...
Kanwal M. Hameed +13 more
doaj +1 more source
Steric Effect in Threshold Photoionization Dissociations of Serine Conformers [PDF]
arXiv, 2008 Steric effect in the threshold dissociative ionizations of serine conformers [CH2OH-C\alphaH(NH2)-C\betaOOH] is revealed by high-level ab initio calculations combined with our newly developed infrared laser desorption / tunable VUV photoionization mass spectrometry.
arxiv
A Mathematical Description of Bacterial Chemotaxis in Response to Two Stimuli [PDF]
arXiv, 2020 Bacteria are often exposed to multiple stimuli in complex environments, and their efficient chemotactic decisions are critical to survive and grow in their native environments. Bacterial responses to the environmental stimuli depend on the ratio of their corresponding chemoreceptors.
arxiv
D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?
Frontiers in Psychiatry, 2019 D-Serine is a potent co-agonist at the NMDA glutamate receptor and has been the object of many preclinical studies to ascertain the nature of its metabolism, its regional and cellular distribution in the brain, its physiological functions and its ...
Mary-Anne B. MacKay +5 more
semanticscholar +1 more source
Kunstfaglig tilnærming til Samisk kulturformidling [PDF]
, 2023 Rammeplanen legger nå føringer for Samisk innhold i barnehagen for både Samiske barnehager og de ikke-Samiske barnehagene. I rammeplanen står det at barnehagen skal fremme respekt for menneskeverdet ved å synliggjøre, verdsette og fremme mangfold og ...
Løvberg, Serine
core