Results 81 to 90 of about 776,967 (309)

Contribution of serine racemase/d-serine pathway to neuronal apoptosis. [PDF]

, 2012
Recent data indicate that age-related N-methyl-d-aspartate receptor (NMDAR) transmission impairment is correlated with the reduction in serine racemase (SR) expression and d-serine content.
F. Florenzano, N. Canu, Ciotti, M, Esposito, S, CANU, NADIA, A. Pristerà, T. Borsello, Cavallaro, S, Manni, L, Pollegioni, L, Pristerà, A, L. Manni, A. Felsani, Felsani, A, S. Cavallaro, Maresca, G, Ciotti, MT, S. Esposito, G. Maresca, Florenzano, F, Borsello, T, M. Ciotti, L. Pollegioni, Canu, N   +23 more
core   +2 more sources

Dual targeting of glutamine and serine metabolism in acute myeloid leukemia

Frontiers in Oncology
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy characterized by disrupted blood cell production and function. Recent investigations have highlighted the potential of targeting glutamine metabolism as a promising therapeutic ...
Kanwal M. Hameed, Kanwal M. Hameed, Dominique R. Bollino, Dominique R. Bollino, Dominique R. Bollino, Amol C. Shetty, Brandon Carter-Cooper, Rena G. Lapidus, Rena G. Lapidus, Rena G. Lapidus, Ashkan Emadi, Ashkan Emadi, Ashkan Emadi, Ashkan Emadi   +13 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Genetic Profiles Affect the Biological Effects of Serine on Gastric Cancer Cells

Frontiers in Pharmacology, 2020
A high serine content in body fluid was identified in a portion of patients with gastric cancer, but its biological significance was not clear. Here, we investigated the biological effect of serine on gastric cancer cells.
Jun Li, Hongzhang Xue, Zhen Xiang, Shuzheng Song, Ranlin Yan, Jun Ji, Zhenggang Zhu, Chaochun Wei, Chaochun Wei, Yingyan Yu   +9 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Serine synthesis and transport mediate the synergistic and detoxifying effects of lienal peptides on cisplatin

Frontiers in Pharmacology
Lienal peptides (LPs), one kind of animal-derived traditional Chinese medicine, are used clinically as an adjunctive therapeutic drug in oncology. Cisplatin (DDP) is a broad-spectrum chemotherapy drug widely used for non-small cell lung cancer (NSCLC ...
Ke Ding, Tengjie Yu, Xiaowei Zhang, Kangrui Hu, Shuying Mao, Tingting Zhang, Ye Liu, Zhongbo Wang, Xin Fan, Wei Liu, Dianzhui Zhang, Laipeng He, Lin Xie, Guangji Wang, Yan Liang   +14 more
doaj   +1 more source

Serine Supports IL-1β Production in Macrophages Through mTOR Signaling

Frontiers in Immunology, 2020
Intracellular metabolic programs tightly regulate the functions of macrophages, and previous studies have shown that serine mainly shapes the macrophage function via one-carbon metabolism.
Siyuan Chen, Yaoyao Xia, Fang He, Jian Fu, Zhongquan Xin, Baichuan Deng, Liuqin He, Xihong Zhou, Wenkai Ren   +8 more
doaj   +1 more source

An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice [PDF]

, 2005
Forkhead-associated (FHA) domains are modular phosphopeptide recognition motifs with a striking preference for phosphothreonine-containing epitopes. FHA domains have been best characterized in eukaryotic signaling pathways but have been identified in six
Curry, JM, Strom, M, Buxton, RS, Whalan, R, Hunt, DM, Colston, MJ, Smerdon, SJ, Gohil, K, Rickman, L   +8 more
core  

Glycosyltransferase Inhibitors:  Synthesis of d-threo-PDMP, l-threo-PDMP, and Other Brain Glucosylceramide Synthase Inhibitors from d- or l-Serine

, 2016
The synthesis of enantiomerically pure (1S,2S)-1-phenyl-2-decanoylamino-3-N-morpholino-1-propanol (l-threo-PDMP) (1a) from l-serine, and the enantiomer (1R,2R)-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (d-threo-PDMP] (1b) from d-serine is reported.
Hossein Razavi (623198), Scott A. Mitchell (1811113), Bryan D. Oates (2224711), Robin Polt (1313058)   +3 more
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source