Results 71 to 80 of about 744,331 (313)

An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice [PDF]

, 2005
Forkhead-associated (FHA) domains are modular phosphopeptide recognition motifs with a striking preference for phosphothreonine-containing epitopes. FHA domains have been best characterized in eukaryotic signaling pathways but have been identified in six
Curry, JM, Strom, M, Buxton, RS, Whalan, R, Hunt, DM, Colston, MJ, Smerdon, SJ, Gohil, K, Rickman, L   +8 more
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Overdose of D-serine Induces Movement Disorder and Neuromuscular Changes of Zebrafish Larvae [PDF]

, 2014
D-serine is a well-known activator of N-methyl-D-aspartate receptors; however, little is known about the teratogenic effects of D-serine overdose during early embryonic development.
Chen, Xing-Guang; Wang, Yun-Hsin; Wen, Chi-Chung; Chen, Yau-Hung, Chi-Chung Wen, Yun-Hsin Wang, Xing-Guang Chen, Yau-Hung Chen   +4 more
core   +1 more source

Free radical destruction of hydroxyl-containing amino acids

Журнал Белорусского государственного университета: Химия, 2019
А new way of the free radical ROS- and HOCl-induced destruction of serine, threonine, and their peptide derivatives due to the nitrogen-centered radicals formation and their subsequent decomposition with the side chain elimination has been established ...
Anastasia A. Sladkova, Irina P. Edimecheva, Anna A. Sosnovskaya, Oleg I. Shadyro   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Functional studies of serine/threonine protein kinase signalling in Mycobacterium tuberculosis. [PDF]

, 2006
Fork-head associated (FHA) domains function in the assembly of signalling complexes through specific interactions with phospho-threonine motifs. FHA domains are found in eukaryotes, and intriguingly in a subset of bacterial species including Mycobacteria
Patel, D.P.
core  

Inhibition of the Alanine-Serine-Cysteine‑1 Transporter by BMS-466442

, 2019
Experiment and modeling were combined to understand inhibition of the alanine-serine-cysteine-1 (asc1) transporter. The structure–activity relationship (SAR) was explored with synthesis of analogues of BMS-466442.
Andrés A. Trabanco, Aránzazu Garcı́a Molina (6458399), Gary Tresadern, Susana Conde-Ceide, Susana Conde-Ceide (1326192), Hilde Lavreysen (836508), Leonardo Pardo (206449), Ivan R. Torrecillas, Andrés A. Trabanco (1367745), Ana Isabel de Lucas (2030461), Gary Tresadern (836509), Hilde Lavreysen, Ivan R. Torrecillas (2228977), Ana Isabel de Lucas, Aránzazu Garcı́a Molina, Leonardo Pardo   +15 more
core   +1 more source

Mendelian Randomization Study With Clinical Follow‐Up Links Metabolites to Risk and Severity of Pulmonary Arterial Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Pulmonary arterial hypertension (PAH) exhibits phenotypic heterogeneity and variable response to therapy. The metabolome has been implicated in the pathogenesis of PAH, but previous works have lacked power to implicate specific metabolites ...
Elham Alhathli, Thomas Julian, Zain Ul Abideen Girach, A. A. Roger Thompson, Christopher Rhodes, Stefan Gräf, Niamh Errington, Martin R. Wilkins, Allan Lawrie, Dennis Wang, Johnathan Cooper‐Knock   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source