Results 71 to 80 of about 725,864 (316)

Inhibition of the Alanine-Serine-Cysteine‑1 Transporter by BMS-466442

, 2019
Experiment and modeling were combined to understand inhibition of the alanine-serine-cysteine-1 (asc1) transporter. The structure–activity relationship (SAR) was explored with synthesis of analogues of BMS-466442.
Andrés A. Trabanco, Aránzazu Garcı́a Molina (6458399), Gary Tresadern, Susana Conde-Ceide, Susana Conde-Ceide (1326192), Hilde Lavreysen (836508), Leonardo Pardo (206449), Ivan R. Torrecillas, Andrés A. Trabanco (1367745), Ana Isabel de Lucas (2030461), Gary Tresadern (836509), Hilde Lavreysen, Ivan R. Torrecillas (2228977), Ana Isabel de Lucas, Aránzazu Garcı́a Molina, Leonardo Pardo   +15 more
core   +1 more source

Repurposed Single Inhibitor for Serine Protease and Spike Glycoproteins of SAR-CoV-2

, 2020
In this research, structure of SARS-CoV-2 spike glycoprotein S1 and S2 along with TMPRSS2, TMPRSS4, TMPRSS11A, TMPRSS11D and TMPRSS11E serine protease (which activates S1 and S2) are used for docking with repurposed inhibitor drug molecules.
Mohtasheemul, Hassan, Tanzila, Arshad, Hamdullah, Khadim Sheikh, Iqra, Arshad, Zainab Sher, Mohammad   +4 more
core   +1 more source

Overdose of D-serine Induces Movement Disorder and Neuromuscular Changes of Zebrafish Larvae [PDF]

, 2014
D-serine is a well-known activator of N-methyl-D-aspartate receptors; however, little is known about the teratogenic effects of D-serine overdose during early embryonic development.
Chen, Xing-Guang; Wang, Yun-Hsin; Wen, Chi-Chung; Chen, Yau-Hung, Chi-Chung Wen, Yun-Hsin Wang, Xing-Guang Chen, Yau-Hung Chen   +4 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Free radical destruction of hydroxyl-containing amino acids

Журнал Белорусского государственного университета: Химия, 2019
А new way of the free radical ROS- and HOCl-induced destruction of serine, threonine, and their peptide derivatives due to the nitrogen-centered radicals formation and their subsequent decomposition with the side chain elimination has been established ...
Anastasia A. Sladkova, Irina P. Edimecheva, Anna A. Sosnovskaya, Oleg I. Shadyro   +3 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Mendelian Randomization Study With Clinical Follow‐Up Links Metabolites to Risk and Severity of Pulmonary Arterial Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Pulmonary arterial hypertension (PAH) exhibits phenotypic heterogeneity and variable response to therapy. The metabolome has been implicated in the pathogenesis of PAH, but previous works have lacked power to implicate specific metabolites ...
Elham Alhathli, Thomas Julian, Zain Ul Abideen Girach, A. A. Roger Thompson, Christopher Rhodes, Stefan Gräf, Niamh Errington, Martin R. Wilkins, Allan Lawrie, Dennis Wang, Johnathan Cooper‐Knock   +10 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Toth, Julia, Wilhelm J. Schwaeble, Christopher Furze, Russell Wallis, Keeble, A. H., Julia Toth, Keeble, Anthony H., Girija, Umakhanth Venkatraman, Wallis, Russell, Mitchell, D. A., Daniel A. Mitchell, Toth, J., Schwaeble, W. J., Schwaeble, Wilhelm J., Anthony H. Keeble, Furze, C., Umakhanth Venkatraman Girija, Furze, Christopher M., Mitchell, Daniel A., Wallis, R., Venkatraman Girija, U.   +20 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source