Results 91 to 100 of about 776,967 (309)

Supplementation of serine in low-gossypol cottonseed meal-based diet improved egg white gelling and rheological properties by regulating ovomucin synthesis and magnum physiological function in laying hens

Journal of Integrative Agriculture
This study examined the effect of dietary serine (Ser) on egg white quality, ovomucin content of laying hens fed low-gossypol cottonseed meal (LCSM)-based diet and sought to explore the regulatory mechanism underlying the effects.
Jianmin Zhou, Yu Fu, Uchechukwu Edna Obianwuna, Jing Wang, Haijun Zhang, Xiubo Li, Guanghai Qi, Shugeng Wu   +7 more
doaj   +1 more source

Serine Alleviates Dextran Sulfate Sodium-Induced Colitis and Regulates the Gut Microbiota in Mice

Frontiers in Microbiology, 2018
Serine alleviates inflammatory responses and is beneficial for gut health; however, whether it exerts any effects on ulcerative colitis or regulates intestinal microbiota remains unknown.
Haiwen Zhang, Haiwen Zhang, Rui Hua, Rui Hua, Bingxi Zhang, Bingxi Zhang, Xiaomeng Zhang, Xiaomeng Zhang, Hui Yang, Hui Yang, Xihong Zhou   +10 more
doaj   +1 more source

Regulation of serine racemase activity by d-serine and nitric oxide in human glioblastoma cells.

, 2006
In the human glioblastoma cell line U87, the activity of serine racemase (SR), catalyzing the isomerisation of serine, was inversely regulated by D-serine and nitric oxide (NO), a neuromodulator and a neurotransmitter, respectively.
CIAMPA, Anna Rosa, MARIOTTO, Sofia Giovanna, SHOJI, Kazuo, SUZUKI, Hisanori   +3 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Targeting SHMT2‐mediated membrane phospholipid remodeling for enhanced anti‐GCSCs treatment

Interdisciplinary Medicine
Cancer stem cells exhibit flexible metabolic profiles. However, the underlying mechanisms for differential metabolic pathways affecting stemness maintenance in gastric cancer are poorly understood.
Liping Yang, Fangli Liao, Yanran Tong, Tong Huang, Yan‐e Du, Siyang Wen, Linshan Jiang, Lanlang Peng, Hua Sun, Gaoli Zhang, Weixian Chen   +10 more
doaj   +1 more source

Molecular structure of a 5,10‐methylenetetrahydrofolate dehydrogenase from the silkworm Bombyx mori

FEBS Open Bio, 2019
The enzyme 5,10‐methylenetetrahydrofolate dehydrogenase (MTHFD) is essential for the production of certain amino acids (glycine, serine, and methionine) and nucleic acids (thymidylate and purine).
Mohammad R. Haque, Akifumi Higashiura, Atsushi Nakagawa, Aiko Hirowatari, Shigeki Furuya, Kohji Yamamoto   +5 more
doaj   +1 more source

Concentration of L-serine and D-serine (six rats per group).

, 2013
(A) Concentration of L-serine in the blood (F1, 41 = 195.04, P = 0.000). (B) Concentration of L-serine in the cortex ipsilateral to pMCAO (different treatments: F2, 1 = 875.18, P = 0.000; different time points: F2, 6 = 104.91, P = 0.000).
Guang-Wei Zhao (426416), Guo-Hua Wang (426415), Li Sun (4624), Zheng-Lin Jiang (426414), Rui Jiang (264894), Le-Yang Han (426417), Tao-Jie Ren (426412), Ren Qiang (426413)   +7 more
core   +1 more source

Significance of the D-Serine-Deaminase and D-Serine Metabolism of Staphylococcus saprophyticus for Virulence [PDF]

, 2013
Staphylococcus saprophyticus is the only species of Staphylococcus that is typically uropathogenic and possesses a gene coding for a D-serine-deaminase (DsdA).
Nielsen, Hailyn V, Sakinc, Turkan, Kline, Kimberly A., Gatermann, Sören G., Korte-Berwanger, Miriam, Hultgren, Scott, Gatermann, Soren G, Nielsen, Hailyn V., Kline, Kimberly   +8 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source