Results 101 to 110 of about 1,088,700 (412)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

A systematically-revised ribosome profiling method for bacteria reveals pauses at single-codon resolution

eLife, 2019
In eukaryotes, ribosome profiling provides insight into the mechanism of protein synthesis at the codon level. In bacteria, however, the method has been more problematic and no consensus has emerged for how to best prepare profiling samples.
Fuad Mohammad, Rachel Green, Allen R Buskirk   +2 more
doaj   +1 more source

Phosphatidylethanolamine homeostasis under conditions of impaired CDP-ethanolamine pathway or phosphatidylserine decarboxylation

Frontiers in Nutrition, 2023
Phosphatidylethanolamine is the major inner-membrane lipid in the plasma and mitochondrial membranes. It is synthesized in the endoplasmic reticulum from ethanolamine and diacylglycerol (DAG) by the CDP-ethanolamine pathway and from phosphatidylserine by
Michaela St Germain, Roya Iraji, Marica Bakovic   +2 more
doaj   +1 more source

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

Nature Communications, 2018
Phosphoglycerate dehydrogenase (PHGDH) catalyzes the committed step in de novo serine biosynthesis. Paradoxically, PHGDH and serine synthesis are required in the presence of abundant environmental serine even when serine uptake exceeds the requirements ...
M. A. Reid, Annamarie E. Allen, Shiyu Liu, Maria V. Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Y. Liu, L. Lai, J. Locasale   +11 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Androgen receptor phosphorylation at serine 308 and serine 791 predicts enhanced survival in castrate resistant prostate cancer patients [PDF]

, 2013
We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and may contribute to prostate cancer development and progression.
Black, Callewaert, Chen, Claire Adams, Clare Orange, Fu, Gaughan, Gioeli, Gioeli, Gordon, Hsu, Jennifer Willder, Joanne Edwards, Kirkegaard, Lin, Lindsay Bennett, Mahajan, Mark Underwood, Mccall, Mccall, Mellinghoff, Pamela McCall, Ponguta, Rochette-Egly, Shigemura, Tahir Qayyum, Tam, Taneja, Traynor, Van Laar, Wen, Willder, Wong, Zhou, Zong   +34 more
core   +3 more sources

Contribution of serine racemase/d‐serine pathway to neuronal apoptosis [PDF]

Aging Cell, 2012
SummaryRecent data indicate that age‐related N‐methyl‐d‐aspartate receptor (NMDAR) transmission impairment is correlated with the reduction in serine racemase (SR) expression and d‐serine content. As apoptosis is associated with several diseases and conditions that generally occur with age, we investigated the modulation of SR/d‐serine pathway during ...
Esposito Simona, Pristerà Andrea, Maresca Giovanna, Felsani Armando, o Florenzano Fulvio, Manni Luigi, Ciotti Maria T, Pollegioni Loredano, Borsello Tiziana, Canu Nadia, Cavallaro Sebastiano   +10 more
openaire   +8 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The Relationship Between Cognitive Distortions and ADHD After Accounting for Depression, Anxiety, and Personality Pathology [PDF]

, 2016
Adults with attention-deficit/hyperactivity disorder (ADHD) suffer from numerous difficulties in daily functioning and, unfortunately, the medications that are typically the first-line of treatment do not ameliorate many of these issues.
Serine, Amelia
core   +1 more source

Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

, 2019
Erratum for: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Bardeesy, N., Boukhali, M., Chen, T., Dyson, N., Gu, H., Haas, W., Hammerman, P., Hayes, D., Hayward, M., Karnik, R., Kottakis, F., Li, Y., Liesa, M., Meissner, A., Nagle, J., Nicolay, B., Roumane, A., Shirihai, O., Wong, K.   +18 more
core   +1 more source