Results 181 to 190 of about 938,109 (291)

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

open access: yesAdvanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni   +12 more
wiley   +1 more source

The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury. [PDF]

open access: yesCell Metab
Novak JSS   +21 more
europepmc   +1 more source

SYNTHESIS OF SERINE

open access: yesJournal of Biological Chemistry, 1936
Herbert E. Carter, Lee R. Schiltz
openaire   +2 more sources

Restoration of SIRT3 Expression in Aged Mice Alleviates UUO‐Induced Renal Fibrosis by Reducing GSK‐3β Hyperacetylation

open access: yesAdvanced Science, EarlyView.
SIRT3 expression is significantly downregulated in the aged kidney, rendering the kidney more vulnerable to fibrotic changes in obstructive nephropathy. By promoting GSK‐3β deacetylation, SIRT3 indirectly inhibits Wnt/β‐catenin signaling, thereby suppressing renal fibrosis.
Jing Wang   +11 more
wiley   +1 more source

ON THE SYNTHESIS OF SERINE

open access: yesJournal of Biological Chemistry, 1940
John Wood, Vincent du Vigneaud
openaire   +2 more sources

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