Results 11 to 20 of about 1,019,815 (341)
Serine-Selective Bioconjugation
Journal of the American Chemical Society, 2020 The first general method for the rapid, chemoselective, and modular functionalization of serine residues in native polypeptides is reported. Using a reagent platform based on P(V) oxidation state, this redox-economic approach can be used to append nearly any kind of cargo onto serine generating a stable, benign, and hydrophilic phosphorothioate linkage.
Julien C. Vantourout +17 more
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Gas-phase basicities of serine and dipeptides of serine and glycine [PDF]
Journal of the American Society for Mass Spectrometry, 1994 The gas-phase basicities of serine and dipeptides containing amino acid residues of serine and glycine were determined by proton transfer reactions in a Fourier transform ion cyclotron resonance mass spectrometer. The gas-phase basicity (GB) of L-serine was found to be 205.9 kcal/mol, with addition of a hydroxymethyl group (-CH2OH) increasing the ...
Christina E. A. Beltrame +2 more
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Serine one-carbon catabolism with formate overflow [PDF]
, 2016 Serine catabolism to glycine and a one-carbon unit has been linked to the anabolic requirements of proliferating mammalian cells. However, genome-scale modeling predicts a catabolic role with one-carbon release as formate. We experimentally prove that in
Athineos, Dimitris +11 more
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Characterization of serine proteinase expression in agaricus bisporus and coprinopsis cinerea by using green fluorescent protein and the A. bisporus SPR1 Promoter [PDF]
, 2008 The Agaricus bisporus serine proteinase 1 (SPR1) appears to be significant in both mycelial nutrition and senescence of the fruiting body.
Andy M. Bailey +13 more
core +4 more sources
IUBMB Life, 2009 AbstractOver one third of all known proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most predominant genetic expansion yielding the enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis, and immunity.
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PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis
Cell Reports, 2017 Molecular signatures are emerging determinants of choice of therapy for lung adenocarcinomas. An evolving therapeutic approach includes targeting metabolic dependencies in cancers.
Boxi Zhang +7 more
doaj +1 more source
The Bacillus subtilis signaling protein SpoIVB defines a new family of serine peptidases [PDF]
, 2002 The protein SpoIVB plays a key role in signaling in the sigma (K) checkpoint of Bacillus subtilis. This regulatory mechanism coordinates late gene expression during development in this organism and we have recently shown SpoIVB to be a serine peptidase ...
Brannigan, J A, Cutting, S M, Hoa, N T
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Serine Transhydroxymethylase [PDF]
Journal of Biological Chemistry, 1973 Abstract Studies of the reversible interconversion of glycine and serine catalyzed by rabbit liver serine transhydroxymethylase in the presence and in the absence of tetrahydrofolate are described. The studies include measurements of pH-rate profiles, isotope effects, and spectral properties of the enzyme-substrate complexes.
Ming S. Chen, LaVerne Schirch
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Cell Reports, 2017 Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive ...
Jeff Charles Kremer +18 more
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