Results 11 to 20 of about 1,088,700 (412)

Serine and glycine metabolism in cancer

Trends in Biochemical Sciences, 2014
Serine and glycine are biosynthetically linked, and together provide the essential precursors for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth. Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. A crucial contribution of serine/glycine to
Gerry Melino, Gerry Melino, Alexey V. Antonov, Ivano Amelio, Francesca Cutruzzolà, Massimiliano Agostini   +5 more
openaire   +6 more sources

THE SYNTHESIS OF SERINE

Journal of Biological Chemistry, 1934
Max S. Dunn, C. Ernst Redemann, Nathaniel Smith   +2 more
openalex   +3 more sources

An atlas of substrate specificities for the human serine/threonine kinome

Nature, 2023
Protein phosphorylation is one of the most widespread post-translational modifications in biology^ 1 , 2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and ...
Jared L. Johnson, Tomer M. Yaron, Emily M Huntsman, A. Kerelsky, Junho Song, Amit Regev, Ting Lin, Katarina M Liberatore, Daniel M. Cizin, Benjamin M. Cohen, N. Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, N. Käufer, M. Dorovkov, A. Ryazanov, Y. Takagi, Edward R. Kastenhuber, M. Goncalves, B. Hopkins, O. Elemento, D. Taatjes, A. Maucuer, A. Yamashita, A. Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, R. Linding, J. Blenis, P. Hornbeck, B. Turk, M. Yaffe, L. Cantley   +39 more
semanticscholar   +1 more source

Insulin-regulated serine and lipid metabolism drive peripheral neuropathy

Nature, 2023
Serine deficiency can increase small fibre neuropathy in wild-type mice and serine replacement in diabetic mice alleviates diabetic neuropathy, directly linking amino acid metabolism to peripheral nerve disorders.
Michal K. Handzlik, Jivani M. Gengatharan, Katie Frizzi, G. McGregor, C. Martino, Gibraan Rahman, Antonio González, Ana M. Moreno, Courtney R. Green, L. Guernsey, Terry Lin, Patrick Tseng, Yoichiro Ideguchi, Regis Fallon, A. Chaix, Satchidananda Panda, P. Mali, M. Wallace, R. Knight, M. Gantner, N. Calcutt, Christian M. Metallo   +21 more
semanticscholar   +1 more source

Serine Metabolism in Health and Disease and as a Conditionally Essential Amino Acid

Nutrients, 2022
L-serine plays an essential role in a broad range of cellular functions including protein synthesis, neurotransmission, and folate and methionine cycles and synthesis of sphingolipids, phospholipids, and sulphur containing amino acids.
M. Holeček
semanticscholar   +1 more source

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

Nature Communications, 2021
Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in mice.
Mylène Tajan, Marc Hennequart, E. Cheung, F. Zani, A. Hock, Nathalie M. Legrave, O. Maddocks, R. Ridgway, D. Athineos, A. Suárez‐Bonnet, R. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, G. Vlachogiannis, N. Valeri, N. Mainolfi, Vipin Suri, Adam J. Friedman, M. Manfredi, K. Blyth, O. Sansom, K. Vousden   +22 more
semanticscholar   +1 more source

Serine-Selective Bioconjugation

Journal of the American Chemical Society, 2020
The first general method for the rapid, chemoselective, and modular functionalization of serine residues in native polypeptides is reported. Using a reagent platform based on P(V) oxidation state, this redox-economic approach can be used to append nearly any kind of cargo onto serine generating a stable, benign, and hydrophilic phosphorothioate linkage.
Julien C. Vantourout, Philip E. Dawson, Gonçalo J. L. Bernardes, Gonçalo J. L. Bernardes, Martin D. Eastgate, Michael J. Deery, Rohan R. Merchant, Antonio Ramirez, Justine N. deGruyter, Katarzyna Maziarz, Natalia M. Padial, Michael A. Schmidt, Srinivasa Rao Adusumalli, Alena Istrate, Dillon T. Flood, Kyle W. Knouse, Jennifer X. Qiao, Phil S. Baran   +17 more
openaire   +8 more sources

Gas-phase basicities of serine and dipeptides of serine and glycine [PDF]

Journal of the American Society for Mass Spectrometry, 1994
The gas-phase basicities of serine and dipeptides containing amino acid residues of serine and glycine were determined by proton transfer reactions in a Fourier transform ion cyclotron resonance mass spectrometer. The gas-phase basicity (GB) of L-serine was found to be 205.9 kcal/mol, with addition of a hydroxymethyl group (-CH2OH) increasing the ...
Christina E. A. Beltrame, John W. McKieman, Carolyn J. Cassady   +2 more
openaire   +3 more sources

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

Journal of Biological Chemistry, 1998
When mammalian cell cultures or mice are exposed to ionizing radiation in survivable or lethal amounts, novel mass components are found in the histone H2A region of two-dimensional gels.
E. Rogakou, D. Pilch, A. Orr, V. Ivanova, W. Bonner   +4 more
semanticscholar   +1 more source

Expression of Formate-Tetrahydrofolate Ligase Did Not Improve Growth but Interferes With Nitrogen and Carbon Metabolism of Synechocystis sp. PCC 6803

Frontiers in Microbiology, 2020
The introduction of alternative CO2-fixing pathways in photoautotrophic organism may improve the efficiency of biological carbon fixation such as minimizing the carbon loss due to photorespiration.
Shanshan Song, Stefan Timm, Steffen N. Lindner, Viktoria Reimann, Wolfgang R. Hess, Martin Hagemann, Eva-Maria Brouwer   +6 more
doaj   +1 more source