Results 11 to 20 of about 1,068,757 (265)
Serine Metabolism in Health and Disease and as a Conditionally Essential Amino Acid
Nutrients, 2022 L-serine plays an essential role in a broad range of cellular functions including protein synthesis, neurotransmission, and folate and methionine cycles and synthesis of sphingolipids, phospholipids, and sulphur containing amino acids.
M. Holeček
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Frontiers in Chemistry, 2022 We determined the kinetic isotope effect on the serine hydroxymethyltransferase reaction (SHMT), which provides important C1 metabolites that are essential for the biosynthesis of DNA bases, O-methyl groups of lignin and methane. An isotope effect on the
Gerd Gleixner
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Effects of insufficient serine on health and selenoprotein expression in rats and their offspring
Frontiers in Nutrition, 2022 ObjectiveTo observe the impact of insufficient exogenous and/or endogenous serine on selenoprotein expression and health of pregnant rats and their offspring.MethodExperiment 1 was conducted in male rats, in which the dose-dependent effects of serine on ...
Yiqun Liu +8 more
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Radical Teacher, 2020 In this essay combining first-person narrative and scholarly literature, a classroom teacher examines the ways in which, despite having a self-professed goal of teaching for social justice, her syllabus centers, upholds, and normalize default whiteness ...
Andrea Serine Avery
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Mapping the Substrate-Binding Sites in the Phosphatidylserine Synthase in Candida albicans
Frontiers in Cellular and Infection Microbiology, 2021 The fungal phosphatidylserine (PS) synthase, a membrane protein encoded by the CHO1 gene, is a potential drug target for pathogenic fungi, such as Candida albicans. However, both substrate-binding sites of C.
Yue Zhou +2 more
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Frontiers in Pharmacology, 2022 Glioma is one of the most lethal cancers and causes more than 200,000 deaths every year. Immunotherapy was an inspiring therapy for multiple cancers but failed in glioma treatment.
Siliang Chen +9 more
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Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma
Molecular & Cellular Oncology, 2021 The rate-limiting enzyme of serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), contributes to rapid growth and proliferation when it is overexpressed in cancer.
Richa Rathore, Brian Van Tine
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Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC
Frontiers in Pharmacology, 2023 Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis.
Kaixuan Wang +8 more
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Molecules, 2020 A synthetic strategy for the preparation of two orthogonally protected methyl esters of the non-proteinogenic amino acid 2,3-l-diaminopropanoic acid (l-Dap) was developed. In these structures, the base-labile protecting group 9-fluorenylmethyloxycarbonyl
Andrea Temperini +5 more
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Cells, 2022 Overexpression of α-synuclein with tyrosine mutated to phenylalanine at position 125 leads to a severe phenotype with motor impairment and neuropathology in Drosophila.
Louise Berkhoudt Lassen +7 more
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