Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF]
, 2012 Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key ...
Clark, Peter M. +8 more
core +2 more sources
Genetic Profiles Affect the Biological Effects of Serine on Gastric Cancer Cells
Frontiers in Pharmacology, 2020 A high serine content in body fluid was identified in a portion of patients with gastric cancer, but its biological significance was not clear. Here, we investigated the biological effect of serine on gastric cancer cells.
Jun Li +9 more
doaj +1 more source
Making serine integrases work for us [PDF]
, 2017 DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
Stark, W. Marshall
core +1 more source
KLHL12 promotes non-lysine ubiquitination of the dopamine receptors D-4.2 and D-4.4, but not of the ADHD-associated D-4.7 variant [PDF]
, 2015 Dopamine D-4 Receptor Polymorphism : The dopamine D-4 receptor has an important polymorphism in its third intracellular loop that is intensively studied and has been associated with several abnormal conditions, among others, attention deficit ...
Lintermans, Béatrice +3 more
core +7 more sources
Serine Supports IL-1β Production in Macrophages Through mTOR Signaling
Frontiers in Immunology, 2020 Intracellular metabolic programs tightly regulate the functions of macrophages, and previous studies have shown that serine mainly shapes the macrophage function via one-carbon metabolism.
Siyuan Chen +8 more
doaj +1 more source
Androgen receptor phosphorylation at serine 308 and serine 791 predicts enhanced survival in castrate resistant prostate cancer patients [PDF]
, 2013 We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and may contribute to prostate cancer development and progression.
Black +34 more
core +3 more sources
Serine Alleviates Dextran Sulfate Sodium-Induced Colitis and Regulates the Gut Microbiota in Mice
Frontiers in Microbiology, 2018 Serine alleviates inflammatory responses and is beneficial for gut health; however, whether it exerts any effects on ulcerative colitis or regulates intestinal microbiota remains unknown.
Haiwen Zhang +10 more
doaj +1 more source
Roles and regulation of membrane-associated serine proteases [PDF]
, 2007 Pericellular proteolytic activity affects many aspects of cellular behaviour, via mechanisms involving processing of the extracellular matrix, growth factors and receptors.
Bass, Rosemary +4 more
core +1 more source
ترشيد أدوار المرأة في فكر الإمام يوسف القرضاوي
مجلة كلية الشريعة والدراسات الإسلاميةأهداف البحث: الاهتداء لمنهجية القرضاوي في ترشيد أدوار المرأة المسلمة، والاعتناء بالمفاهيم والأصول الكبرى التي احتكم إليها في بناء موقفه، واستثمار ما توصل إليه في تعميق أداء المسلمة لواجباتها في واقعنا المعاصر.
Serine Louiz
doaj +1 more source
Molecular structure of a 5,10‐methylenetetrahydrofolate dehydrogenase from the silkworm Bombyx mori
FEBS Open Bio, 2019 The enzyme 5,10‐methylenetetrahydrofolate dehydrogenase (MTHFD) is essential for the production of certain amino acids (glycine, serine, and methionine) and nucleic acids (thymidylate and purine).
Mohammad R. Haque +5 more
doaj +1 more source