Results 11 to 20 of about 1,010,564 (310)

tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury

Neurobiology of Disease, 2014
Although tissue plasminogen activator (tPA) is known to promote neuronal remodeling in the CNS, no mechanism of how this plastic function takes place has been reported so far.
Sighild Lemarchant, Mathilde Pruvost, Marie Hébert, Maxime Gauberti, Yannick Hommet, Aurélien Briens, Eric Maubert, Yatma Gueye, François Féron, Didier Petite, Marcel Mersel, Jean-Claude do Rego, Hubert Vaudry, Jari Koistinaho, Carine Ali, Véronique Agin, Evelyne Emery, Denis Vivien   +17 more
doaj   +1 more source

The metabolic reprogramming and vulnerability of SF3B1 mutations

Molecular & Cellular Oncology, 2020
Mutations in the splicing factor 3b subunit 1 (SF3B1) gene create a neomorphic protein that disrupts RNA splicing, but the downstream consequences of this missplicing are unclear.
W. Brian Dalton
doaj   +1 more source

Influence of increasing glycine concentrations in reduced crude protein diets fed to broilers from 0 to 48 days

Poultry Science, 2022
: Two experiments investigated broiler growth performance and processing characteristics when fed increasing Gly concentrations in reduced CP diets fed from 0 to 48 d.
D. Trevor Lee, Jason T. Lee, Chuanmin Ruan, Samuel J. Rochell   +3 more
doaj   +1 more source

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]

, 2003
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Bieber, Boer, Chung, Decker, Gabrilove, Gonzalez, Goodnough, Gotoh, Haq, Jain, Jain, Jonk, Kaptein, Kirito, Kirito, Kirito, Lim, Millot, Miyazaki, Mulcahy, Ng, Schuringa, Schuringa, Schuringa, Smithgall, Socolovsky, Teglund, Tilbrook, Turkson, Watowich, Wen, Wen, Woetmann, Yokogami, Youssoufian, Yu, Zhang   +36 more
core   +1 more source

When and where? Pathogenic Escherichia coli differentially sense host D-serine using a universal transporter system to monitor their environment [PDF]

, 2016
Sensing environmental stimuli is critically important for bacteria when faced with the multitude of adversities presented within the host. Responding appropriately to these signals and in turn integrating these responses into the regulatory network of ...
Connolly, James P.R., Roe, Andrew J.
core   +2 more sources

Orchestrating serine resolvases [PDF]

Biochemical Society Transactions, 2010
A remarkable feature of the serine resolvases is their regulation: the wild-type enzymes will catalyse intra- but not inter-molecular recombination, can sense the relative orientation of their sites and can exchange strands directionally, despite the fact that there is no net release of chemical bond energy.
Phoebe A, Rice, Kent W, Mouw, Sherwin P, Montaño, Martin R, Boocock, Sally-J, Rowland, W Marshall, Stark   +5 more
openaire   +2 more sources

Dual Effects of Beta-Hydroxy-Beta-Methylbutyrate (HMB) on Amino Acid, Energy, and Protein Metabolism in the Liver and Muscles of Rats with Streptozotocin-Induced Type 1 Diabetes

Biomolecules, 2020
Beta-hydroxy-beta-methyl butyrate (HMB) is a unique product of leucine catabolism with positive effects on protein balance. We have examined the effects of HMB (200 mg/kg/day via osmotic pump for 7 days) on rats with diabetes induced by streptozotocin ...
Milan Holeček, Melita Vodeničarovová, Radana Fingrová   +2 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

Serine Resolvases [PDF]

Microbiology Spectrum, 2015
ABSTRACT Serine resolvases are an interesting group of site-specific recombinases that, in their native contexts, resolve large fused replicons into smaller separated ones. Some resolvases are encoded by replicative transposons and resolve the transposition product, in which the donor and recipient molecules are fused, into separate replicons.
openaire   +2 more sources

Different concentrations of cysteamine, ergothioneine, and serine modulate quality and fertilizing ability of cryopreserved chicken sperm

Poultry Science, 2020
The aim of this study was to evaluate the effects of freezing diluents supplemented in three potential amines/amino acids, namely, antioxidant cysteamine (2-aminoethanethiol [AET]), ergothioneine (ERG), and serine (SER), in optimization of chicken sperm ...
Pachara Thananurak, Napapach Chuaychu-noo, Aurore Thélie, Yupin Phasuk, Thevin Vongpralub, Elisabeth Blesbois   +5 more
doaj   +1 more source