Results 11 to 20 of about 725,864 (316)
Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma
Molecular & Cellular Oncology, 2021 The rate-limiting enzyme of serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), contributes to rapid growth and proliferation when it is overexpressed in cancer.
Richa Rathore, Brian Van Tine
doaj +1 more source
Mapping the ACE2 binding site on the SARS-CoV-2 spike protein S1: molecular recognition pattern [PDF]
Proceedings of the Estonian Academy of Sciences, 2020 Coronavirus SARS-CoV-2 enters the host cell via binding with the angiotensin-converting enzyme 2 (ACE2), and here we used computational modelling to study the molecular recognition pattern of this interaction.
Aleksei Kuznetsov, Jaak Järv
doaj +1 more source
Serine-Selective Bioconjugation
Journal of the American Chemical Society, 2020 The first general method for the rapid, chemoselective, and modular functionalization of serine residues in native polypeptides is reported. Using a reagent platform based on P(V) oxidation state, this redox-economic approach can be used to append nearly any kind of cargo onto serine generating a stable, benign, and hydrophilic phosphorothioate linkage.
Vantourout, Julien C +16 more
openaire +7 more sources
Neurobiology of Disease, 2014 Although tissue plasminogen activator (tPA) is known to promote neuronal remodeling in the CNS, no mechanism of how this plastic function takes place has been reported so far.
Sighild Lemarchant +17 more
doaj +1 more source
Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]
, 2003 Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Eggen, BJL +8 more
core +1 more source
Seprase: An overview of an important matrix serine protease [PDF]
, 2008 Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
O\u27Brien, Pamela +3 more
core +1 more source
IUBMB Life, 2009 AbstractOver one third of all known proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most predominant genetic expansion yielding the enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis, and immunity.
openaire +3 more sources
T-SP1: a novel serine protease-like protein predominantly expressed in testis [PDF]
, 2008 Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue.
Nerlich, Andreas +6 more
core +1 more source
Cellular Redox Imbalance and Neurochemical Effect in Cognitive-Deficient Old Rats
Behavioral Sciences, 2018 The purpose of the present study is to access the linkage between dysregulation of glutamatergic neurotransmission, oxidative metabolism, and serine signaling in age-related cognitive decline.
Maria Elena González-Fraguela +5 more
doaj +1 more source
, 2023 3,3′,5,5′-Tetramethylbenzidine (TMB)-based catalysis-mediated colorimetric analysis for the detection of small molecules has poor specificity. In this study, well-prepared Au@Cu2O core–shell nanocatalysts (NCs) were fabricated that have excellent ...
Wei-Peng Li (703383) +5 more
core +1 more source