Results 241 to 250 of about 938,109 (291)
Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy
This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou+13 more
wiley +1 more source
Unveiling the Multifaceted Role of HP6: A Critical Regulator of Humoral Immunity in <i>Antheraea pernyi</i> (Lepidoptera: Saturniidae). [PDF]
Liu C+6 more
europepmc +1 more source
Clinical discovery and the proposed underlying mechanism by how P. johnsonii ameliorated metabolic disorders. Abstract The gut bacterium Parabacteroides spp. is increasingly recognized for its therapeutic potential in treating metabolic disorders. However, the role of Parabacteroides johnsonii in metabolic disorders is never reported.
Yimeng Chen+9 more
wiley +1 more source
Functional characterization of a common XIa inhibitory Kunitz-domain Shp4 from nine schistosoma secreted proteins with diverse C-terminal fragments. [PDF]
Ye X+10 more
europepmc +1 more source
Acute restraint stress enhances STAT3Ser727 phosphorylation in dopaminergic neurons in mice. This modification promotes the upregulation of GABBR2 and GABRB3, reduces neuronal activity, and contributes to anxiety‐like behavior and diminished reward‐seeking following stress exposure.
Mingshuo Shao+10 more
wiley +1 more source
Update of the sideroflexin (SLC56) gene family. [PDF]
Katsafadou AI+4 more
europepmc +1 more source
The study reveals that PAXIP1‐associated glutamate‐rich protein 1 (PAGR1), a glucose‐responsive regulator in skeletal muscle, modulates systemic glucose homeostasis and hepatic metabolism. Muscle‐specific PAGR1 deletion enhances insulin signaling, promotes glucose transporter 4 (GLUT4) translocation, and protects against high‐fat‐diet‐induced insulin ...
Chenyun Ding+19 more
wiley +1 more source
Novilysobacter viscosus sp. Nov. and Novilysobacter longmucuonensis sp. Nov., two Nov.l species capable of producing proteases and RiPPs. [PDF]
Phurbu D+5 more
europepmc +1 more source
NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu+15 more
wiley +1 more source