Results 241 to 250 of about 951,429 (338)

Serine metabolism in tumor progression and immunotherapy. [PDF]

Discov Oncol
Huang D, Cai H, Huang H.
europepmc   +1 more source

A new method for the synthesis of serine ethanolamine phosphate [PDF]

, 1968
Anthony K. Allen
openalex   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation. [PDF]

Cell Death Dis
Lv M, Duan Z, Tan J, Liu J, Wang Q, Wang C, Zhang Z, Sun X, Liu R, Cui Y.   +9 more
europepmc   +1 more source

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou, Meng Gao, Shikun Zhang, Wing‐Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma   +10 more
wiley   +1 more source

Enhanced l-serine synthesis in <i>Corynebacterium glutamicum</i> by exporter engineering and Bayesian optimization of the medium composition. [PDF]

Synth Syst Biotechnol
Huang Y, Gao Y, Huang Y, Wang X, Xu M, Xu G, Zhang X, Li H, Shi J, Xu Z, Zhang X.   +10 more
europepmc   +1 more source

The Magnesium-Dependent Incorporation of Serine into the Phospholipids of Mitochondria Isolated from the Developing Flight Muscle of the African Locust Locusta migratoria [PDF]

, 1969
Fyfe L. Bygrave, Werner M. Kaiser
openalex   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis. [PDF]

Theranostics
Yagi H, Qiu C, Zeng Y, Boeck M, Nian S, Chen CT, Harman JC, Kasai T, Lee J, Hirst V, Neilsen K, Wang C, Bora K, Maurya M, Rodrick T, Grumbine M, Yang Y, Hua Z, Sweet IR, Singh SA, Aikawa M, Chen J, Fu Z.   +22 more
europepmc   +1 more source

The Rate of Turnover of Serine and Phosphoserine in Rat Liver

, 1960
Martin Nemer, Edmund M. Wise, Florinell M. Washington, David H. Elwyn   +3 more
openalex   +1 more source