Results 261 to 270 of about 776,967 (309)
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On the nucleophilicity of serine in enzymes
Journal of Theoretical Biology, 1968Abstract Certain anionic nucleophiles containing cationic groups possess higher reactivities in displacement reactions with neutral substrates than would be predicted from their aqueous basicities. The explanation for this behavior has been applied to show how the serine moiety in an enzyme with, perhaps, relatively small assistance from a ...
J, Epstein, H O, Michel, W A, Mosher
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Synthesis of photodeprotectable serine derivatives. “Caged serine”
Bioorganic & Medicinal Chemistry Letters, 1992Abstract The synthesis of O-(4,5-dimethoxy-2-nitrobenzyl)serine has been accomplished by treatment of an FMOC-aziridinecarboxylate with nitroveratryl alcohol followed by hydrolysis. Irradiation with a Pyrex-filtered 450W Hanovia lamp releases serine with a half-life of 4.4 min. o-Nitrobenzyl serinate is prepared by direct esterification.
Michael C. Pirrung, David S. Nunn
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Serine metabolism and psychosis
Psychiatry Research, 1984Plasma serine levels (PSL) in a group of patients with the diagnosis of major or atypical psychoses were significantly higher than in patients with nonpsychotic diagnoses or nonpatient controls. The enzyme serine hydroxymethyltransferase (SHMT), which metabolizes serine to glycine, showed abnormal activity in the psychotics compared to nonpsychotics ...
R, Waziri +3 more
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Current Opinion in Clinical Nutrition and Metabolic Care, 2013
Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity.D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms.
Inna, Radzishevsky +2 more
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Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity.D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms.
Inna, Radzishevsky +2 more
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ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
Cell Reports, 2021Junran Zhang +2 more
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Serine hydroxymethyltransferase activity and serine incorporation in leukocytes.
Cancer research, 1979Studies of serine hydroxymethyltransferase activity in extracts of leukocytes from normal and leukemic subjects showed that the enzyme is present in lymphocytes and granulocytes but that activity is higher in lymphocytes. It is also higher than normal in lymphocytes from patients with chronic lymphocytic leukemia and to a lesser extent in the ...
J, Thorndike, T T, Pelliniemi, W S, Beck
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Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis
Cellular and Molecular Immunology, 2022Qiujing Yu, Penghui Hu, Zemin Ji
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