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Serine racemase and the serine shuttle between neurons and astrocytes
Biochimica Et Biophysica Acta - Proteins and Proteomics, 2011d-Serine is a brain-enriched d-amino acid that works as a transmitter-like molecule by physiologically activating NMDA receptors. Synthesis of d-serine is carried out by serine racemase (SR), a pyridoxal 5'-phosphate-dependent enzyme. In addition to carry out racemization, SR α,β-eliminates water from l- or d-serine, generating pyruvate and NH(4 ...
Herman Wolosker
exaly +3 more sources
Biochemistry, 2004
Serine palmitoyltransferase (SPT) is a key enzyme in sphingolipid biosynthesis and catalyzes the decarboxylative condensation of L-serine and palmitoyl coenzyme A to 3-ketodihydrosphingosine. We have succeeded in the overproduction of a water-soluble homodimeric SPT from Sphingomonas paucimobilis EY2395(T) in Escherichia coli.
Hiroko, Ikushiro +2 more
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Serine palmitoyltransferase (SPT) is a key enzyme in sphingolipid biosynthesis and catalyzes the decarboxylative condensation of L-serine and palmitoyl coenzyme A to 3-ketodihydrosphingosine. We have succeeded in the overproduction of a water-soluble homodimeric SPT from Sphingomonas paucimobilis EY2395(T) in Escherichia coli.
Hiroko, Ikushiro +2 more
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Mechanism of eukaryotic serine racemase-catalyzed serine dehydration
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020Eukaryotic serine racemase (SR) is a pyridoxal 5'-phosphate enzyme belonging to the Fold-type II group, which catalyzes serine racemization and is responsible for the synthesis of D-Ser, a co-agonist of the N-methyl-d-aspartate receptor. In addition to racemization, SR catalyzes the dehydration of D- and L-Ser to pyruvate and ammonia.
Tomokazu, Ito +8 more
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ChemBioChem, 2015
Oxazetidine assisted KAHA ligation was developed by the Bode group as an efficient peptide segment ligation strategy at native serine residues. This milestone achievement should enable the chemical synthesis of difficult-to-prepare proteins for biological studies.
Yi-Ming, Li, Yi-Chao, Huang, Lei, Liu
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Oxazetidine assisted KAHA ligation was developed by the Bode group as an efficient peptide segment ligation strategy at native serine residues. This milestone achievement should enable the chemical synthesis of difficult-to-prepare proteins for biological studies.
Yi-Ming, Li, Yi-Chao, Huang, Lei, Liu
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On the nucleophilicity of serine in enzymes
Journal of Theoretical Biology, 1968Abstract Certain anionic nucleophiles containing cationic groups possess higher reactivities in displacement reactions with neutral substrates than would be predicted from their aqueous basicities. The explanation for this behavior has been applied to show how the serine moiety in an enzyme with, perhaps, relatively small assistance from a ...
J, Epstein, H O, Michel, W A, Mosher
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Synthesis of photodeprotectable serine derivatives. “Caged serine”
Bioorganic & Medicinal Chemistry Letters, 1992Abstract The synthesis of O-(4,5-dimethoxy-2-nitrobenzyl)serine has been accomplished by treatment of an FMOC-aziridinecarboxylate with nitroveratryl alcohol followed by hydrolysis. Irradiation with a Pyrex-filtered 450W Hanovia lamp releases serine with a half-life of 4.4 min. o-Nitrobenzyl serinate is prepared by direct esterification.
Michael C. Pirrung, David S. Nunn
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Serine metabolism and psychosis
Psychiatry Research, 1984Plasma serine levels (PSL) in a group of patients with the diagnosis of major or atypical psychoses were significantly higher than in patients with nonpsychotic diagnoses or nonpatient controls. The enzyme serine hydroxymethyltransferase (SHMT), which metabolizes serine to glycine, showed abnormal activity in the psychotics compared to nonpsychotics ...
R, Waziri +3 more
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Current Opinion in Clinical Nutrition and Metabolic Care, 2013
Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity.D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms.
Inna, Radzishevsky +2 more
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Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity.D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms.
Inna, Radzishevsky +2 more
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Serine hydroxymethyltransferase activity and serine incorporation in leukocytes.
Cancer research, 1979Studies of serine hydroxymethyltransferase activity in extracts of leukocytes from normal and leukemic subjects showed that the enzyme is present in lymphocytes and granulocytes but that activity is higher in lymphocytes. It is also higher than normal in lymphocytes from patients with chronic lymphocytic leukemia and to a lesser extent in the ...
J, Thorndike, T T, Pelliniemi, W S, Beck
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