Results 271 to 280 of about 725,864 (316)
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Synthesis of photodeprotectable serine derivatives. “Caged serine”
Bioorganic & Medicinal Chemistry Letters, 1992Abstract The synthesis of O-(4,5-dimethoxy-2-nitrobenzyl)serine has been accomplished by treatment of an FMOC-aziridinecarboxylate with nitroveratryl alcohol followed by hydrolysis. Irradiation with a Pyrex-filtered 450W Hanovia lamp releases serine with a half-life of 4.4 min. o-Nitrobenzyl serinate is prepared by direct esterification.
Michael C. Pirrung, David S. Nunn
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Serine hydroxymethyltransferase revisited
Current Opinion in Chemical Biology, 2005Recent structural data and the properties of several active site mutants of serine hydroxymethyltransferase have resolved some key questions concerning the catalytic mechanism and broad substrate specificity of this enzyme. In the tetrahydrofolate-dependent conversion of serine to glycine, an early proposed mechanism involved a retroaldol cleavage and ...
Verne, Schirch, Doletha Me, Szebenyi
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Crystallization of serine carboxypeptidases
Journal of Molecular Biology, 1990Crystallization of three different serine carboxypeptidases has been achieved by the method of hanging-drop vapor diffusion. Serine carboxypeptidases II from wheat bran and malted barley crystallize isomorphously from polyethylene glycol solutions at room temperature (pH 4 to 7) in space group P4(1)2(1)2 or enantiomorph with cell dimensions of a = b ...
K P, Wilson +4 more
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Journal of Chemical Theory and Computation, 2016
The myriad conformers of the neutral form of natural amino acid serine (Ser) have been investigated by systematic computations with reliable electronic wave function methods. A total of 85 unique conformers were located using the MP2/cc-pVTZ level of theory.
Kedan, He, Wesley D, Allen
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The myriad conformers of the neutral form of natural amino acid serine (Ser) have been investigated by systematic computations with reliable electronic wave function methods. A total of 85 unique conformers were located using the MP2/cc-pVTZ level of theory.
Kedan, He, Wesley D, Allen
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Serine metabolism and psychosis
Psychiatry Research, 1984Plasma serine levels (PSL) in a group of patients with the diagnosis of major or atypical psychoses were significantly higher than in patients with nonpsychotic diagnoses or nonpatient controls. The enzyme serine hydroxymethyltransferase (SHMT), which metabolizes serine to glycine, showed abnormal activity in the psychotics compared to nonpsychotics ...
R, Waziri +3 more
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On the nucleophilicity of serine in enzymes
Journal of Theoretical Biology, 1968Abstract Certain anionic nucleophiles containing cationic groups possess higher reactivities in displacement reactions with neutral substrates than would be predicted from their aqueous basicities. The explanation for this behavior has been applied to show how the serine moiety in an enzyme with, perhaps, relatively small assistance from a ...
J, Epstein, H O, Michel, W A, Mosher
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Refolding of serine proteinases
Journal of Cellular Biochemistry, 1986AbstractBovine trypsinogen and chymotrypsinogen were successfully refolded as the mixed disulfide of glutathione using cysteine as the disulfide interchange catalyst. The native structures were regenerated with yields of 40%–50% at pH 8.6 and 4 °C, and the half‐time for the refolding was approximately 60–75 min.
A, Light +3 more
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Current Opinion in Neurology, 2004
Serine-deficiency disorders comprise a new group of neurometabolic diseases and are caused by defects in the biosynthesis of the amino acid L-serine. In contrast to most neurometabolic disorders, serine-deficiency disorders are potentially treatable. Furthermore, the severe neurological symptoms observed in patients underscore the important roles of ...
Tom J, de Koning, Leo W J, Klomp
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Serine-deficiency disorders comprise a new group of neurometabolic diseases and are caused by defects in the biosynthesis of the amino acid L-serine. In contrast to most neurometabolic disorders, serine-deficiency disorders are potentially treatable. Furthermore, the severe neurological symptoms observed in patients underscore the important roles of ...
Tom J, de Koning, Leo W J, Klomp
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Homologies in serine proteinases
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1970Abstract Bovine pancreatic juice contains approximately equal amounts of four inactive precursors of endopeptidases (zymogens): chymotrypsinogen A, chymotrypsinogen B, trypsinogen (Keller, Cohen & Neurath 1958) and a component of procarboxypeptidase which resembles a chymotrypsinogen (Brown, Greenshields, Yamasaki & Neurath ...
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Serine hydroxymethyltransferase activity and serine incorporation in leukocytes.
Cancer research, 1979Studies of serine hydroxymethyltransferase activity in extracts of leukocytes from normal and leukemic subjects showed that the enzyme is present in lymphocytes and granulocytes but that activity is higher in lymphocytes. It is also higher than normal in lymphocytes from patients with chronic lymphocytic leukemia and to a lesser extent in the ...
J, Thorndike, T T, Pelliniemi, W S, Beck
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