Results 251 to 260 of about 725,864 (316)

SNHG12 drives gastric cancer progression by activating the Wnt/β-catenin-mediated serine synthesis pathway. [PDF]

J Transl Med
Zhang N, Li T, Wen K.
europepmc   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Evidence of transfer of antimicrobial resistance genes from the porcine pathogen <i>Streptococcus suis</i> to human clinical isolates of <i>Streptococcus agalactiae</i> in a major pig-producing region of Spain. [PDF]

One Health
Uruén C, Lavilla MJ, Libante V, Marín CM, Rezusta A, Payot S, Arenas J.   +6 more
europepmc   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

PRSS23 promotes ovarian cancer peritoneal dissemination independent of protease activity. [PDF]

J Biol Chem
Akhtar S, Coban M, Miller E, Hockla A, Maina E, Mehner C, Ilic S, Papo N, Radisky DC, Radisky ES.   +9 more
europepmc   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Correction: Acylation of Lysine 983 Is Sufficient for Toxin Activity of Bordetella pertussis Adenylate Cyclase. [PDF]

J Biol Chem
Basar T, Havlíček V, Bezoušková S, Hackett M, Ŝebo P.   +4 more
europepmc   +1 more source

The tumor suppressor NDRG2 recruits protein phosphatase 2A to suppress STAT5 phosphorylation in adult T-cell leukemia/lymphoma. [PDF]

J Biol Chem
Ichikawa T, Nakahata S, Shimoda K, Murakami T, Morishita K.   +4 more
europepmc   +1 more source

Sulfur-Containing Amino Acids: The Conversion Process from Product to Substrate. [PDF]

Int J Mol Sci
Zheng P, Jin Y, Wei C, Xia C.
europepmc   +1 more source