Results 241 to 250 of about 1,010,564 (310)

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

O-Acetyl-Serine Supplementation Enhances Insulin Secretion and Improves Postprandial Glycaemia in Lean and Prediabetic Mice. [PDF]

FASEB J
Benatar C, Zhang X, Haddam I, Ribes S, Bobet S, Monnoye M, Lamy E, Grassin-Delyle S, Juillard V, Layec S, Delorme C, Douard V.   +11 more
europepmc   +1 more source

A poliubiquitin receptorok fejlődésstádium-specifikus szabályozása Drosophila melanogasterben [PDF]

, 2009
Lipinszki Zoltán
core  

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas. [PDF]

Nat Commun
Aussel A, Nemazanyy I, Vandenberghe A, Meola P, Dorat N, Paul R, Habbouche L, Exposito L, Nottet N, Petrilli V, Chiche E, Mounier N, Marchetti S, Chaveroux C, Ricci JE, Chiche J.   +15 more
europepmc   +1 more source

Biolipid Film‐Fused Electrochemiluminescence for Multipurpose In Situ Bioassays

Advanced Science, EarlyView.
An ECL‐emissive, membrane‐interactive scaffold was fabricated, and facilely fused with natural and non‐native phospholipids into multifactorial mimicries of cytomembranes and vesicles for in vitro representative membrane‐process probing. Such a biointerface‐based, state‐sensitive ECL paradigm not only pinpointed proximal phenomena, including channeling
Jialiang Chen, Bin Li, Yingying Wang, Fulin Zhu, Wenxuan Yang, Xuanyu Fu, Tiantian Man, Qiuyue Wu, Kewei Ren, Shengyuan Deng   +9 more
wiley   +1 more source

Serine synthesis and transport mediate the synergistic and detoxifying effects of lienal peptides on cisplatin. [PDF]

Front Pharmacol
Ding K, Yu T, Zhang X, Hu K, Mao S, Zhang T, Liu Y, Wang Z, Fan X, Liu W, Zhang D, He L, Xie L, Wang G, Liang Y.   +14 more
europepmc   +1 more source

Aspartate availability drives differential engagement of the malate-aspartate shuttle. [PDF]

Mol Cell
Brunner JS, Bridgeman AE, Jackson BT, Chakraborty S, Fagoaga-Eugui M, Paras KI, Xie A, Arnold PK, Losner J, Finley LWS.   +9 more
europepmc   +1 more source

Gold Nanocluster-Amino Acid Interactions: Assessment of DFTB with Dispersion Corrections. [PDF]

ACS Omega
Morehouse J, McPhee A, Howie E, L Oliveira LF.   +3 more
europepmc   +1 more source