Results 271 to 280 of about 938,109 (291)
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KAHA Ligation at Serine

ChemBioChem, 2015
Oxazetidine assisted KAHA ligation was developed by the Bode group as an efficient peptide segment ligation strategy at native serine residues. This milestone achievement should enable the chemical synthesis of difficult-to-prepare proteins for biological studies.
Lei Liu, Yi-Chao Huang, Yi-Ming Li
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On the nucleophilicity of serine in enzymes

Journal of Theoretical Biology, 1968
Abstract Certain anionic nucleophiles containing cationic groups possess higher reactivities in displacement reactions with neutral substrates than would be predicted from their aqueous basicities. The explanation for this behavior has been applied to show how the serine moiety in an enzyme with, perhaps, relatively small assistance from a ...
W.A. Mosher, J. Epstein, H.O. Michel
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Serine racemase and the serine shuttle between neurons and astrocytes

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2011
d-Serine is a brain-enriched d-amino acid that works as a transmitter-like molecule by physiologically activating NMDA receptors. Synthesis of d-serine is carried out by serine racemase (SR), a pyridoxal 5'-phosphate-dependent enzyme. In addition to carry out racemization, SR α,β-eliminates water from l- or d-serine, generating pyruvate and NH(4 ...
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Serine hydroxymethyltransferase revisited

Current Opinion in Chemical Biology, 2005
Recent structural data and the properties of several active site mutants of serine hydroxymethyltransferase have resolved some key questions concerning the catalytic mechanism and broad substrate specificity of this enzyme. In the tetrahydrofolate-dependent conversion of serine to glycine, an early proposed mechanism involved a retroaldol cleavage and ...
Verne Schirch, Doletha M. E. Szebenyi
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Conformers of Gaseous Serine

Journal of Chemical Theory and Computation, 2016
The myriad conformers of the neutral form of natural amino acid serine (Ser) have been investigated by systematic computations with reliable electronic wave function methods. A total of 85 unique conformers were located using the MP2/cc-pVTZ level of theory.
Kedan He, Wesley D. Allen
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Crystallization of serine carboxypeptidases

Journal of Molecular Biology, 1990
Crystallization of three different serine carboxypeptidases has been achieved by the method of hanging-drop vapor diffusion. Serine carboxypeptidases II from wheat bran and malted barley crystallize isomorphously from polyethylene glycol solutions at room temperature (pH 4 to 7) in space group P4(1)2(1)2 or enantiomorph with cell dimensions of a = b ...
Klaus Breddam   +4 more
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Serine metabolism and psychosis

Psychiatry Research, 1984
Plasma serine levels (PSL) in a group of patients with the diagnosis of major or atypical psychoses were significantly higher than in patients with nonpsychotic diagnoses or nonpatient controls. The enzyme serine hydroxymethyltransferase (SHMT), which metabolizes serine to glycine, showed abnormal activity in the psychotics compared to nonpsychotics ...
Rafiq Waziri   +3 more
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An Overview of Serine Proteases [PDF]

open access: possibleCurrent Protocols in Protein Science, 2001
AbstractThis unit summarizes the families of serine proteases and their mechanism of catalysis. Methods for assays and determining substrate specificity are briefly described. The mode of action of commonly available inhibitors is also included.
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Serine-deficiency syndromes

Current Opinion in Neurology, 2004
Serine-deficiency disorders comprise a new group of neurometabolic diseases and are caused by defects in the biosynthesis of the amino acid L-serine. In contrast to most neurometabolic disorders, serine-deficiency disorders are potentially treatable. Furthermore, the severe neurological symptoms observed in patients underscore the important roles of ...
Tom J. de Koning, Leo W. J. Klomp
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Refolding of serine proteinases

Journal of Cellular Biochemistry, 1986
AbstractBovine trypsinogen and chymotrypsinogen were successfully refolded as the mixed disulfide of glutathione using cysteine as the disulfide interchange catalyst. The native structures were regenerated with yields of 40%–50% at pH 8.6 and 4 °C, and the half‐time for the refolding was approximately 60–75 min.
Chester T. Duda   +3 more
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