Results 271 to 280 of about 951,429 (338)

Combining PIM‐2 and PARP1 Inhibitors Induces MICA Expression on Multiple Myeloma Cells to Activate NK Cells through NKG2D Binding

Advanced Science, EarlyView.
The findings suggest that the combination of PIM‐2 and PARP1 inhibitors can induce MICA expression on MM cells, thereby activating NK cells through NKG2D binding. This process may restore NK cell function and serve as a potential therapeutic approach for MM patients. Abstract While immunogenic death in tumor cells activates specific anti‐tumor T cells,
Zhaoyun Liu, Wenhui Lei, Xiaohan Liu, Hui Liu, Kai Ding, Jia Song, Rong Fu   +6 more
wiley   +1 more source

D- and L-Amino Acid Blood Concentrations Are Affected in Children With Duchenne Muscular Dystrophy. [PDF]

J Cell Mol Med
Garofalo M, Panicucci C, Imarisio A, Nuzzo T, Brolatti N, De Stefano ME, Valente EM, Errico F, Bruno C, Usiello A.   +9 more
europepmc   +1 more source

DDX3 Regulates the Cap‐Independent Translation of the Japanese Encephalitis Virus via Its Interactions with PABP1 and the Untranslated Regions of the Viral Genome

Advanced Science, EarlyView.
Japanese encephalitis virus (JEV) employs a cap‐independent (CI) translation strategy to evade host translational shutoff. During the shut‐off of host cellular canonical translation, DEAD‐box protein 3 (DDX3) bind to JEV UTRs to establish a closed‐loop architecture, and its interaction with poly(A)‐binding protein 1 (PABP1) to form DDX3/PABP1/eIF4G ...
Chenxi Li, Linjie Zhang, Chenyang Tang, Xuan Chen, Jing Shi, Qingyu Li, Xue Jiao, Jinyao Guo, Bin Wang, Kefan Bu, Abdul Wahaab, Yuguo Yuan, Ming‐an Sun, Yanhua Li   +13 more
wiley   +1 more source

m⁶A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability. [PDF]

Nat Commun
Huang F, Wang Y, Zhang X, Gao W, Li J, Yang Y, Mo H, Prince E, Long Y, Hu J, Jiang C, Kang Y, Chen Z, Hu YC, Zeng C, Yang L, Chen CW, Chen J, Huang H, Weng H.   +19 more
europepmc   +1 more source

Isolation and Properties of a Homogeneous Preparation of Cystathionine Synthetase-l-Serine and l-Threonine Dehydratase

, 1965
A. Nagabhushanam, David M. Greenberg
openalex   +1 more source

Development and Breeding of Herbicide‐Resistant Sorghum for Effective Cereal‐Legume Intercropping

Advanced Science, EarlyView.
This study identified two SbALS mutations (A93T and S624N) conferring robust herbicide resistance in sorghum, facilitating efficient weed control. Structural analysis revealed that imazamox resistance is mediated by disrupted herbicide binding. Furthermore, 126 imazamox resistant soybean varieties are screened for sorghum‐soybean intercropping ...
Sanyuan Tang, Jiayang Shi, Xuefeng Li, Mingliang Yang, Chao Li, Dan Zhang, Sen Yang, Cuo Mei, Zuyong Luo, Li Zhang, Wanke Zhang, Chunrui Zhang, Chenbo Zhu, Xiaowei Ma, Ran Xia, Yuhang Chen, Jinsong Zhang, Qingshan Chen, Shouyi Chen, Qi Xie, Feifei Yu   +20 more
wiley   +1 more source

A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling. [PDF]

iScience
Dalby A, Kaas M, Meinertz Byg L, Christiansen SB, Longworth CM, Hansen SB, Qvist P, Nyengaard JR, Madsen P, Mølgaard S, Glerup S.   +10 more
europepmc   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

The Use of Intrinsic Disorder and Phosphorylation by Oncogenic Viral Proteins to Dysregulate the Host Cell Cycle Through Interaction with pRb. [PDF]

Viruses
Kast-Woelbern H, Martinho SK, Julio KT, Vazzana AM, Mandagie AE, Jansma AL.   +5 more
europepmc   +1 more source

Phosphatidyl Serine of Bovine Milk

, 1969
Virginia E. Boatman, Stuart Patton, John Parsons   +2 more
openalex   +1 more source