The role of D-serine and glycine as co-agonists of NMDA receptors in motor neuron degeneration and amyotrophic lateral sclerosis (ALS). [PDF]
, 2014 The fundamental role of D-serine as a co-agonist at the N-methyl-D-aspartate receptor (NMDAR), mediating both physiological actions of glutamate in long term potentiation and nociception and also pathological effects mediated by excitotoxicty, are well ...
de Belleroche, J, Paul, P
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IUBMB Life, 2009 AbstractOver one third of all known proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most predominant genetic expansion yielding the enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis, and immunity.
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When and where? Pathogenic Escherichia coli differentially sense host D-serine using a universal transporter system to monitor their environment [PDF]
, 2016 Sensing environmental stimuli is critically important for bacteria when faced with the multitude of adversities presented within the host. Responding appropriately to these signals and in turn integrating these responses into the regulatory network of ...
Connolly, James P.R., Roe, Andrew J.
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Properties of an Extracellular Protease of Bacillus megaterium DSM 319 as Depilating Aid of Hides
Microbiology Indonesia, 2012 Properties of a Bacillus megaterium DSM319 extracellular protease which are related to its application for depilating hides were investigated. The properties observed were optimum temperature and pH, the type of protease, and type of the protein which ...
BUDIASIH WAHYUNTARI +1 more
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Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]
, 2003 Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Bieber +36 more
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Serine Transhydroxymethylase [PDF]
Journal of Biological Chemistry, 1973 Abstract Studies of the reversible interconversion of glycine and serine catalyzed by rabbit liver serine transhydroxymethylase in the presence and in the absence of tetrahydrofolate are described. The studies include measurements of pH-rate profiles, isotope effects, and spectral properties of the enzyme-substrate complexes.
Ming S. Chen, LaVerne Schirch
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Serine restriction alters sphingolipid diversity to constrain tumor growth
Nature, 2020 Serine, glycine and other nonessential amino acids are critical for tumour progression, and strategies to limit their availability are emerging as potential therapies for cancer 1 – 3 .
Thangaselvam Muthusamy +11 more
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Microbiology Spectrum, 2015 ABSTRACT Serine resolvases are an interesting group of site-specific recombinases that, in their native contexts, resolve large fused replicons into smaller separated ones. Some resolvases are encoded by replicative transposons and resolve the transposition product, in which the donor and recipient molecules are fused, into separate replicons.
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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Cancer Discovery, 2020 A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine-limited brain environment restrict metastatic tumor growth.
B. Ngo +39 more
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Mapping the ACE2 binding site on the SARS-CoV-2 spike protein S1: molecular recognition pattern [PDF]
Proceedings of the Estonian Academy of Sciences, 2020 Coronavirus SARS-CoV-2 enters the host cell via binding with the angiotensin-converting enzyme 2 (ACE2), and here we used computational modelling to study the molecular recognition pattern of this interaction.
Aleksei Kuznetsov, Jaak Järv
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