Results 21 to 30 of about 652,471 (299)
Phosphorylation of Calpastatin Negatively Regulates the Activity of Calpain
Life, 2023 Tenderness is an important characteristic of meat quality. Calpastatin and calpain play important roles in meat tenderization. However, it is not clear how phosphorylation affects the regulation of calpastatin on μ-calpain and, consequently, meat ...
Yuqiang Bai +6 more
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Genomic investigation of emerging zoonotic pathogen Shewanella xiamenensis
Tzu Chi Medical Journal, 2020 Objective: Shewanella xiamenensis is an emerging zoonotic pathogen commonly found in aquatic ecosystem. Clustered regularly interspaced short palindromic repeats (CRISPR) and (CRISPR)-associated gene systems act as adaptive immune system of prokaryotes ...
Jui-Hsing Wang +2 more
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Microbiology Spectrum, 2023 Gut microbiota and their secreted metabolites have an influence on the initiation and progression of colon cancer. Probiotics are extensively perceived as a potential microbiota-modulation strategy to promote the health of the host, while the ...
Fuqiang Xu +7 more
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ترشيد أدوار المرأة في فكر الإمام يوسف القرضاوي
مجلة كلية الشريعة والدراسات الإسلاميةأهداف البحث: الاهتداء لمنهجية القرضاوي في ترشيد أدوار المرأة المسلمة، والاعتناء بالمفاهيم والأصول الكبرى التي احتكم إليها في بناء موقفه، واستثمار ما توصل إليه في تعميق أداء المسلمة لواجباتها في واقعنا المعاصر.
Serine Louiz
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Poultry Science, 2022 : Two experiments investigated broiler growth performance and processing characteristics when fed increasing Gly concentrations in reduced CP diets fed from 0 to 48 d.
D. Trevor Lee +3 more
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Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway
Cells, 2019 Tight regulation of signaling from receptor tyrosine kinases is required for normal cellular functions and uncontrolled signaling can lead to cancer. Fibroblast growth factor receptor 2 (FGFR2) is a receptor tyrosine kinase that induces proliferation and
Patrycja Szybowska +4 more
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The metabolic reprogramming and vulnerability of SF3B1 mutations
Molecular & Cellular Oncology, 2020 Mutations in the splicing factor 3b subunit 1 (SF3B1) gene create a neomorphic protein that disrupts RNA splicing, but the downstream consequences of this missplicing are unclear.
W. Brian Dalton
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Biomolecules, 2020 Beta-hydroxy-beta-methyl butyrate (HMB) is a unique product of leucine catabolism with positive effects on protein balance. We have examined the effects of HMB (200 mg/kg/day via osmotic pump for 7 days) on rats with diabetes induced by streptozotocin ...
Milan Holeček +2 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Hans Journal of Biomedicine, 2013 D-丝氨酸主要存在于哺乳动物的前脑，海马区和纹状体，作为胶质细胞释放的神经递质，作用于NMDA (N-methyl-D-aspartate receptor)受体，引起中枢神经系统中信号的传导。在突触可塑性，学习和记忆等方面起重要作用。丝氨酸消旋酶是一种磷酸吡多醛依赖酶，在ATP和Mg2+的辅助下，通过消旋作用将L型丝氨酸转变为D型丝氨酸。对于神经及精神性疾病，丝氨酸消旋酶可能是一个新的治疗靶点。本文从D-丝氨酸和丝氨酸消旋酶的结构性质，作用机理，功能，调控等方面进行了阐述。 D-serine mainly distributed in the mammalian forebrain, hippocampus and striatum, which as neurotransmit-ters ...
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