Results 21 to 30 of about 1,019,815 (341)

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]

open access: yes, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel   +4 more
core   +1 more source

Characterization of the cGMP-dependent protein kinase SmcGK1 of Schistosoma mansoni

open access: yesAnais da Academia Brasileira de Ciências, 2011
Schistosomes are trematode parasites and of worldwide medical importance for humans and animals. Growth and development of these parasites require a specific host environment, but also permanent communication processes between the two genders ...
Silke Leutner   +2 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

open access: yes, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane   +55 more
core   +1 more source

Influence of increasing glycine concentrations in reduced crude protein diets fed to broilers from 0 to 48 days

open access: yesPoultry Science, 2022
: Two experiments investigated broiler growth performance and processing characteristics when fed increasing Gly concentrations in reduced CP diets fed from 0 to 48 d.
D. Trevor Lee   +3 more
doaj   +1 more source

Iterative focused screening with biological fingerprints identifies selective Asc-1 inhibitors distinct from traditional high throughput screening [PDF]

open access: yes, 2017
N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and ...
Amoss, Adam   +18 more
core   +2 more sources

Serine Resolvases [PDF]

open access: yesMicrobiology Spectrum, 2015
ABSTRACT Serine resolvases are an interesting group of site-specific recombinases that, in their native contexts, resolve large fused replicons into smaller separated ones. Some resolvases are encoded by replicative transposons and resolve the transposition product, in which the donor and recipient molecules are fused, into separate replicons.
openaire   +2 more sources

The serine transporter SdaC prevents cell lysis upon glucose depletion in Escherichia coli

open access: yesMicrobiologyOpen, 2020
The amino acid serine plays diverse metabolic roles, yet bacteria actively degrade exogenously provided serine via deamination to pyruvate. Serine deamination is thought to be a detoxification mechanism due to the ability of serine to inhibit several ...
Michelle A. Kriner   +1 more
doaj   +1 more source

Controlled rotation mechanism of DNA strand exchange by the Hin serine recombinase. [PDF]

open access: yes, 2016
DNA strand exchange by serine recombinases has been proposed to occur by a large-scale rotation of halves of the recombinase tetramer. Here we provide the first direct physical evidence for the subunit rotation mechanism for the Hin serine invertase ...
Johnson, Reid C   +4 more
core   +1 more source

Biosynthesis of food constituents: Amino acids: 2. The alanine-valine-leucine, serine-cysteine-glycine, and aromatic and heterocyclic amino acids groups - a review

open access: yesCzech Journal of Food Sciences, 2006
This review article gives a survey of principal pathways that lead to the biosynthesis of the proteinogenic amino acids of the alanine-valine-leucine group starting with pyruvic acid from the glycolytic pathway and serine-cysteine-glycine group starting ...
Jan Velíšek, Karel Cejpek
doaj   +1 more source

Making serine integrases work for us [PDF]

open access: yes, 2017
DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
Stark, W. Marshall
core   +1 more source

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