Results 51 to 60 of about 1,088,700 (412)
Iterative focused screening with biological fingerprints identifies selective Asc-1 inhibitors distinct from traditional high throughput screening [PDF]
, 2017 N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and ...
Amoss, Adam +18 more
core +2 more sources
The Effect of Single and Multiple SERAT Mutants on Serine and Sulfur Metabolism
Frontiers in Plant Science, 2018 The gene family of serine acetyltransferases (SERATs) constitutes an interface between the plant pathways of serine and sulfur metabolism. SERATs provide the activated precursor, O-acetylserine for the fixation of reduced sulfur into cysteine by ...
Mutsumi Watanabe +5 more
doaj +1 more source
Amino acid frequency and domain features serve well for random forest based classification of thermophilic and mesophilic protein; a case study on serine proteases [PDF]
arXiv, 2021 Thermostability is an important prerequisite for enzymes employed for industrial applications. Several machine learning based models have thus been formulated for protein classification based on this particular trait. These models have employed features derived from sequences, structures or both resulting in a >93% accuracy based on a 10-fold cross ...
arxiv
Extracellular serine controls epidermal stem cell fate and tumor initiation
Nature Cell Biology, 2020 Tissue stem cells are the cell of origin for many malignancies. Metabolites regulate the balance between self-renewal and differentiation, but whether endogenous metabolic pathways or nutrient availability predispose stem cells towards transformation ...
Sanjeethan C. Baksh +9 more
semanticscholar +1 more source
Making serine integrases work for us [PDF]
, 2017 DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
Stark, W. Marshall
core +1 more source
ترشيد أدوار المرأة في فكر الإمام يوسف القرضاوي
مجلة كلية الشريعة والدراسات الإسلاميةأهداف البحث: الاهتداء لمنهجية القرضاوي في ترشيد أدوار المرأة المسلمة، والاعتناء بالمفاهيم والأصول الكبرى التي احتكم إليها في بناء موقفه، واستثمار ما توصل إليه في تعميق أداء المسلمة لواجباتها في واقعنا المعاصر.
Serine Louiz
doaj +1 more source
Biochemical Journal, 2001 Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases, minimally containing a well conserved catalytic subunit, the activity of which is highly regulated.
V. Janssens, J. Goris
semanticscholar +1 more source
On nonemptiness of Newton strata in the $B_\mathrm{dR}^+$-Grassmannian for $\mathrm{GL}_n$ [PDF]
arXiv, 2022 We study the Newton stratification in the $B_\mathrm{dR}^+$-Grassmannian for $\mathrm{GL}_n$ associated to an arbitrary (possibly nonbasic) element of $B(\mathrm{GL}_n)$. Our main result classifies all nonempty Newton strata in an arbitrary minuscule Schubert cell. For a large class of elements in $B(\mathrm{GL}_n)$, our classification is given by some
arxiv
On the Hodge-Newton filtration for p-divisible groups of Hodge type [PDF]
Math. Z. 291 (2019) 473-497, 2016 A p-divisible group, or more generally an F-crystal, is said to be Hodge-Newton reducible if its Hodge polygon passes through a break point of its Newton polygon. Katz proved that Hodge-Newton reducible F-crystals admit a canonical filtration called the Hodge-Newton filtration.
arxiv +1 more source
Microbiology Spectrum, 2014 ABSTRACTIn site-specific recombination, two short DNA sequences (‘sites’) are each cut at specific points in both strands, and the cut ends are rejoined to new partners. The enzymes that mediate recognition of the sites and the subsequent cutting and rejoining steps are called recombinases.
openaire +3 more sources