Results 51 to 60 of about 1,068,757 (265)
Frontiers in Endocrinology, 2018 Serine has recently been shown to reduce oxidative stress and inflammation, which, when occurring in the hypothalamus, contribute to age-related obesity. To explore whether long-term serine administration reduces oxidative stress and body weight in aging
Xihong Zhou +5 more
doaj +1 more source
On the Hodge-Newton filtration for p-divisible groups of Hodge type [PDF]
Math. Z. 291 (2019) 473-497, 2016 A p-divisible group, or more generally an F-crystal, is said to be Hodge-Newton reducible if its Hodge polygon passes through a break point of its Newton polygon. Katz proved that Hodge-Newton reducible F-crystals admit a canonical filtration called the Hodge-Newton filtration.
arxiv +1 more source
The Bacillus subtilis signaling protein SpoIVB defines a new family of serine peptidases [PDF]
, 2002 The protein SpoIVB plays a key role in signaling in the sigma (K) checkpoint of Bacillus subtilis. This regulatory mechanism coordinates late gene expression during development in this organism and we have recently shown SpoIVB to be a serine peptidase ...
Brannigan, J A, Cutting, S M, Hoa, N T
core +2 more sources
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy.
New England Journal of Medicine, 2019 BACKGROUND Identifying mechanisms of diseases with complex inheritance patterns, such as macular telangiectasia type 2, is challenging. A link between macular telangiectasia type 2 and altered serine metabolism has been established previously.
M. Gantner +31 more
semanticscholar +1 more source
One-carbon metabolism in cancer [PDF]
, 2017 Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane +55 more
core +1 more source
On nonemptiness of Newton strata in the $B_\mathrm{dR}^+$-Grassmannian for $\mathrm{GL}_n$ [PDF]
arXiv, 2022 We study the Newton stratification in the $B_\mathrm{dR}^+$-Grassmannian for $\mathrm{GL}_n$ associated to an arbitrary (possibly nonbasic) element of $B(\mathrm{GL}_n)$. Our main result classifies all nonempty Newton strata in an arbitrary minuscule Schubert cell. For a large class of elements in $B(\mathrm{GL}_n)$, our classification is given by some
arxiv
NRF2 regulates serine biosynthesis in non-small cell lung cancer
Nature Genetics, 2015 Tumors have high energetic and anabolic needs for rapid cell growth and proliferation, and the serine biosynthetic pathway was recently identified as an important source of metabolic intermediates for these processes.
G. DeNicola +13 more
semanticscholar +1 more source
Iterative focused screening with biological fingerprints identifies selective Asc-1 inhibitors distinct from traditional high throughput screening [PDF]
, 2017 N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and ...
Amoss, Adam +18 more
core +2 more sources
Harris-Viehmann conjecture for Hodge-Newton reducible Rapoport-Zink spaces [PDF]
J. London Math. Soc., 98 (2018) 733-752, 2016 Rapoport-Zink spaces, or more generally local Shimura varieties, are expected to provide geometric realization of the local Langlands correspondence via their $l$-adic cohomology. Along this line is a conjecture by Harris and Viehmann, which roughly says that when the underlying local Shimura datum is not basic, the $l$-adic cohomology of the local ...
arxiv +1 more source
Biochemical Journal, 2001 Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases, minimally containing a well conserved catalytic subunit, the activity of which is highly regulated.
V. Janssens, J. Goris
semanticscholar +1 more source