Results 51 to 60 of about 1,019,815 (341)

A conditional marker gene allowing both positive and negative selection in plants [PDF]

, 2004
Selectable markers enable transgenic plants or cells to be identified after transformation. They can be divided into positive and negative markers conferring a selective advantage or disadvantage, respectively.
Erikson, Oskar, Hertzberg, Magnus, Näsholm, Torgny   +2 more
core   +1 more source

Serine phosphorylation of STATs [PDF]

Oncogene, 2000
Tyrosine phosphorylation regulates the dimerization of STATs as an essential prerequisite for the establishment of a classical JAK-STAT signaling path. However, most vertebrate STATs contain a second phosphorylation site within their C-termini. The phosphorylated residue in this case is a serine contained within a P(M)SP motif, and in the majority of ...
Pavel Kovarik, Thomas Decker
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Personal model‐assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD

Molecular Systems Biology, 2017
To elucidate the molecular mechanisms underlying non‐alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS).
Adil Mardinoglu, Elias Bjornson, Cheng Zhang, Martina Klevstig, Sanni Söderlund, Marcus Ståhlman, Martin Adiels, Antti Hakkarainen, Nina Lundbom, Murat Kilicarslan, Björn M Hallström, Jesper Lundbom, Bruno Vergès, Peter Hugh R Barrett, Gerald F Watts, Mireille J Serlie, Jens Nielsen, Mathias Uhlén, Ulf Smith, Hanns‐Ulrich Marschall, Marja‐Riitta Taskinen, Jan Boren   +21 more
doaj   +1 more source

Genomic investigation of emerging zoonotic pathogen Shewanella xiamenensis

Tzu Chi Medical Journal, 2020
Objective: Shewanella xiamenensis is an emerging zoonotic pathogen commonly found in aquatic ecosystem. Clustered regularly interspaced short palindromic repeats (CRISPR) and (CRISPR)-associated gene systems act as adaptive immune system of prokaryotes ...
Jui-Hsing Wang, Shu-Ying Tseng, Kwong-Chung Tung   +2 more
doaj   +1 more source

RNA polymerase II stalling promotes nucleosome occlusion and pTEFb recruitment to drive immortalization by Epstein-Barr virus [PDF]

, 2011
Epstein-Barr virus (EBV) immortalizes resting B-cells and is a key etiologic agent in the development of numerous cancers. The essential EBV-encoded protein EBNA 2 activates the viral C promoter (Cp) producing a message of ~120 kb that is differentially ...
A Bakos, A Bell, A Dey, A Lin, AI Bell, B Kempkes, B Sugden, BM Peterlin, C Lee, CD Gregory, CF Bourgeois, CH Wu, CH Wu, D Ivanov, DA Gilchrist, DC Hargreaves, DS Gilmour, DS Gilmour, DY Wu, DY Wu, E Johannsen, E Klein, EA Abbate, G Kelly, G Laux, H Gross, H Kirby, Helen M. Webb, I Tempera, J You, JH Yik, JI Cohen, K Fujinaga, KD Robertson, KD Robertson, L Waltzer, L Wang, M Ottinger, M Woisetschlaeger, M Woisetschlaeger, Michelle J. West, MJ West, MK Jang, N Alazard, N Kaplan, NA Brown, NF Marshall, NP Gomes, P Filippakopoulos, Paul M. Lieberman, R Tierney, Richard D. Palermo, S Egloff, S Egloff, S Swaminathan, SH Chao, SJ Bark-Jones, SR Grossman, SY Wu, T Fujita, T Fujita, T Henkel, T Wada, T Wada, U Zimber-Strobl, VT Nguyen, W Lucchesi, W Yue, W Yue, W Yue, W Zhu, X Tong, X Tong, X Tong, YK Kim, Z Yang   +75 more
core   +3 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Serine and glycine metabolism-related gene expression signature stratifies immune profiles of brain gliomas, and predicts prognosis and responses to immunotherapy

Frontiers in Pharmacology, 2022
Glioma is one of the most lethal cancers and causes more than 200,000 deaths every year. Immunotherapy was an inspiring therapy for multiple cancers but failed in glioma treatment.
Siliang Chen, Shuxin Zhang, Shuxin Zhang, Wentao Feng, Junhong Li, Yunbo Yuan, Wenhao Li, Zhihao Wang, Yuan Yang, Yanhui Liu   +9 more
doaj   +1 more source

Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]

, 2018
Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder, Capri, Joseph, Cohn, Whitaker, Faull, Kym F, Freeman, Michael R, Lugea, Aurelia, Pandol, Stephen J, Piplani, Honit, Sakkiah, Sugunadevi, Su, Hsin-Yuan, Waldron, Richard T, Whitelegge, Julian P, Yang, Wei, Zhou, Bo   +13 more
core   +3 more sources

Phosphorylation of mouse serine racemase regulates d‐serine synthesis

FEBS Letters, 2010
Serine racemase (SR) catalyses the synthesis of the transmitter/neuromodulator d‐serine, which plays a major role in synaptic plasticity and N‐methyl d‐aspartate receptor neurotoxicity. We now report that SR is phosphorylated at Thr71 and Thr227 as revealed by mass spectrometric analysis and in vivo phosphorylation assays.
Martin Zehl, Martin Zehl, Veronika N. Foltyn, Elena Dikopoltsev, Herman Wolosker, Ole N. Jensen   +5 more
openaire   +4 more sources