Results 61 to 70 of about 1,088,700 (412)
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy.
New England Journal of Medicine, 2019 BACKGROUND Identifying mechanisms of diseases with complex inheritance patterns, such as macular telangiectasia type 2, is challenging. A link between macular telangiectasia type 2 and altered serine metabolism has been established previously.
M. Gantner +31 more
semanticscholar +1 more source
Конденсированные среды и межфазные границы, 2019 Purpose. The purpose of this paper is to establish the infl uence of the differences in the structural and morphological properties of the surface of Pt and Pt(Pt) electrodes (roughness, in particular) on the basic principles and thermodynamic ...
Kuleshova Nadezhda E. +3 more
doaj +1 more source
Harris-Viehmann conjecture for Hodge-Newton reducible Rapoport-Zink spaces [PDF]
J. London Math. Soc., 98 (2018) 733-752, 2016 Rapoport-Zink spaces, or more generally local Shimura varieties, are expected to provide geometric realization of the local Langlands correspondence via their $l$-adic cohomology. Along this line is a conjecture by Harris and Viehmann, which roughly says that when the underlying local Shimura datum is not basic, the $l$-adic cohomology of the local ...
arxiv +1 more source
cGMP-dependent protein kinase regulates Rap1 signaling in platelets : poster presentation [PDF]
, 2007 cGMP- and cAMP-dependent protein kinases (cGK and cAK) mediate the inhibitory effects of endothelium-derived messenger molecules nitric oxide and prostacyclin on platelets.
Danielewski, Oliver +5 more
core +1 more source
Phosphorylation of mouse serine racemase regulates
FEBS Letters, 2010 Serine racemase (SR) catalyses the synthesis of the transmitter/neuromodulator d‐serine, which plays a major role in synaptic plasticity and N‐methyl d‐aspartate receptor neurotoxicity. We now report that SR is phosphorylated at Thr71 and Thr227 as revealed by mass spectrometric analysis and in vivo phosphorylation assays.
Martin Zehl +5 more
openaire +4 more sources
The content of non-essential amino acids in the grains of winter and spring varieties of oats (Avena sativa L.) under the conditions of Central Southern Bulgaria [PDF]
Agroznanje, 2013 The purpose of this survey is to study the content of non-essential amino acids in four winter (Dunav 1, Ruse 8, Resor 1, Line M-K) and five spring (Obraztsov chiflik 4, Mina, HiFi, Novosadski golozarnest and Prista 2) cultivars of oats grown in Central ...
Georgieva T., Zorovski P.
doaj +1 more source
Seprase: An overview of an important matrix serine protease [PDF]
, 2008 Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
Abbott +115 more
core +1 more source
NRF2 regulates serine biosynthesis in non-small cell lung cancer
Nature Genetics, 2015 Tumors have high energetic and anabolic needs for rapid cell growth and proliferation, and the serine biosynthetic pathway was recently identified as an important source of metabolic intermediates for these processes.
G. DeNicola +13 more
semanticscholar +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source