Results 71 to 80 of about 1,088,700 (412)
Neurobiology of Disease, 2023 L-serine generated in astrocytes plays a pivotal role in modulating essential neurometabolic processes, while its enantiomer, D-serine, specifically regulates NMDA receptor (NMDAR) signalling.
Anna Di Maio +13 more
doaj
Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC
Frontiers in Pharmacology, 2023 Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis.
Kaixuan Wang +8 more
doaj +1 more source
Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF]
, 2012 Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key ...
Clark, Peter M. +8 more
core +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Frontiers in Pharmacology, 2022 Glioma is one of the most lethal cancers and causes more than 200,000 deaths every year. Immunotherapy was an inspiring therapy for multiple cancers but failed in glioma treatment.
Siliang Chen +9 more
doaj +1 more source
On certain extensions of vector bundles in p-adic geometry [PDF]
arXiv, 2020 Given two arbitrary vector bundles on the Fargues-Fontaine curve, we give an explicit criterion in terms of Harder-Narasimhan polygons on whether they realize a semistable vector bundle as their extensions. Our argument is largely combinatorial and builds upon the dimension analysis of certain moduli spaces of bundle maps developed in [BFH+22].
arxiv
Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]
, 2010 Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Debela +21 more
core +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Genetic analyses of the structural protein E2 bovine viral diarrhea virus isolated from dairy cattle in Yogyakarta, Indonesia [PDF]
Veterinary WorldBackground and Aim: Bovine viral diarrhea (BVD), a highly pathogenic ribonucleic acid (RNA) virus, causes devastating financial losses and reproductive deaths among dairy cattle in Yogyakarta and globally.
S. U. Khan +4 more
doaj +1 more source
Molecules, 2021 We compared the efficacy for protein extraction of water versus enzymatic extraction. The amino-acid composition, inhibitory activity against enzymes α-amylase and α-glucosidase, and anti-glycation activities of silk protein extract (SPE) were determined.
Chuleeporn Bungthong +3 more
doaj +1 more source