Results 71 to 80 of about 1,068,757 (265)

A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate

Nature Chemical Biology, 2016
Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH ...
M. Pacold, K. Brimacombe, Sze Ham Chan, J. M. Rohde, C. Lewis, L. Swier, Richard L. Possemato, Walter W. Chen, Lucas B. Sullivan, B. Fiske, Steve Cho, Elizaveta Freinkman, Kıvanç Birsoy, Monther Abu-Remaileh, Y. Shaul, Chieh Min Liu, Minerva Zhou, Min Jung Koh, Haeyoon Chung, S. Davidson, Alba Luengo, Amy Q Wang, Xin Xu, Adam Yasgar, Li Liu, Ganesha Rai, K. Westover, M. V. Vander Heiden, M. Shen, N. Gray, M. Boxer, D. Sabatini   +31 more
semanticscholar   +1 more source

tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury

Neurobiology of Disease, 2014
Although tissue plasminogen activator (tPA) is known to promote neuronal remodeling in the CNS, no mechanism of how this plastic function takes place has been reported so far.
Sighild Lemarchant, Mathilde Pruvost, Marie Hébert, Maxime Gauberti, Yannick Hommet, Aurélien Briens, Eric Maubert, Yatma Gueye, François Féron, Didier Petite, Marcel Mersel, Jean-Claude do Rego, Hubert Vaudry, Jari Koistinaho, Carine Ali, Véronique Agin, Evelyne Emery, Denis Vivien   +17 more
doaj  

Serine Supplementation Alleviates Doxorubicin-Induced Oxidative Damage in Skeletal Muscle of Mice

Frontiers in Physiology, 2021
Muscle weakness affects physical activity and quality of life of patients. Serine, a nutritionally non-essential amino acid has been reported to enhance protein synthesis and implicate in biosynthesis of multiple bioactive molecules.
Jingqing Chen, Jingqing Chen, Xihong Zhou, Xihong Zhou, Hai Jia, Zhenlong Wu   +5 more
doaj   +1 more source

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source

Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli

mBio, 2022
Escherichia coli associates with humans early in life and can occupy several body niches either as a commensal in the gut and vagina, or as a pathogen in the urinary tract. As such, E.
Michelle A. Wiebe, John R. Brannon, Bradley D. Steiner, Adebisi Bamidele, Alexandra C. Schrimpe-Rutledge, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, Maria Hadjifrangiskou   +8 more
doaj   +1 more source

Serine is the major residue for ADP-ribosylation upon DNA damage

eLife, 2018
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-ribosylation (ADPr), a reversible modification of proteins that regulates many different cellular processes.
L. Palazzo, Orsolya Leidecker, Evgeniia A. Prokhorova, Helen Dauben, I. Matic, Ivan Ahel   +5 more
semanticscholar   +1 more source

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

Science, 2018
Mitochondrial serine transporter identified One-carbon (1C) metabolism is a universal metabolic process that is required for purine synthesis and supports the high levels of proliferation in cancer cells.
Nora Kory, Gregory A. Wyant, G. Prakash, Jelmi uit de Bos, Francesca Bottanelli, M. Pacold, Sze Ham Chan, C. Lewis, Tim Wang, Heather R. Keys, Y. Guo, D. Sabatini   +11 more
semanticscholar   +1 more source

Making serine integrases work for us [PDF]

, 2017
DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
Stark, W. Marshall
core   +1 more source

The importance of serine metabolism in cancer

Journal of Cell Biology, 2016
Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells ...
Katherine R. Mattaini, Mark R. Sullivan, M. V. Vander Heiden   +2 more
semanticscholar   +1 more source

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
Abbott, Abbott, Abbott, Acharya, Adams, Adams, Aertgeerts, Aimes, Alcolado, Aoyama, Ariga, Artym, Bangert, Barrett, Bauvois, Bermpohl, Birney, Bissell, Brendan F. O'Connor, Brown, Busek, Chen, Chen, Chen, Chen, Cheng, Cheng, Christiansen, Collins, Corpet, De Wever, Del Rosso, Dolznig, Dvorak, Edosada, Edosada, Fassnacht, Fidler, Fink, Flentke, Fulop, Garcia-Horsman, Garin-Chesa, Gerner, Ghersi, Ghersi, Ghersi, Gilmore, Goldstein, Goldstein, Goodman, Gorrell, Guex, Hofheinz, Huang, Huber, Huber, Ibrahim, Iwasa, Jin, Kelly, Kelly, Kelly, Kelly, Kloft, Koyama, Lee, Lee, Lee, Lee, Lee, Levy, Levy, Levy, Loeffler, Mathew, Mersmann, Milner, Monsky, Mori, Mueller, Nicholas, Niedermeyer, Niedermeyer, Niedermeyer, Oertel, Okada, Okada, Ollis, Pamela O'Brien, Park, Pineiro-Sanchez, Ramirez-Montagut, Rennex, Rettig, Rettig, Rettig, Rettig, Rosenblum, Samel, Scanlan, Schechter, Scott, Scott, Sieweke, Skubitz, Stremenova, Sun, Tahtis, Tran, Wang, Wang, Welt, Welt, Wesley, Zhang   +115 more
core   +1 more source